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<p>Titanium dioxide nanoparticles (TiO<sub>2</sub>NPs) have emerged as leading candidates for diverse biomedical applications. The present work emphasizes characterization along with synthesis of Ag-doped TiO<sub>2</sub>NPs, which possess tuneable physical properties. Titanium isopropoxide or silver nitrate have been utilized as precursors for production of pure and Ag-doped TiO<sub>2</sub>NPs by co-precipitation approach. The as synthesised pure and Ag doped TiO<sub>2</sub>NPs (3%,5% and 7% Ag doped) were subjected to characterisation via FTIR (Fourier Transform Infrared Spectroscopy), X-ray diffraction (XRD), SEM (Scanning Electron Microscopy), Energy Dispersive X-ray Spectroscopy (EDAX), UV-Vis (UV-visible diffuse Reflectance Spectroscopy). XRD spectra confirmed the anatase phase of TiO<sub>2</sub>NPs.UV-Visible spectral analysis revealed that with increasing doping concentration, the bandgap energy decreased progressively. The synthesized samples’ morphology was analyzed by SEM. EDAX analysis confirmed doping. FTIR studies established existence of diverse functional groups in TiO<sub>2</sub>NPs.The in vitro anticancer effect determination in human cancer cell line A549 was evaluated utilizing MTT assay method. From the study, it was found that 7% Ag doped TiO<sub>2</sub> showed the lowest LC₅₀ value of 106.4&#xa0;µg/mL, indicating enhanced anti-proliferative activity.</p>

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Functionalised Ag doped TiO2 nanoparticles for antiproliferative applications in lung cancer therapy

  • 期刊论文

  • 发表日期：

    2026年3月4日

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  • N. G. Jitha,
  • K. Deepa,
  • Krithika Sreekanth,
  • Nandana Prakashan

摘要

Titanium dioxide nanoparticles (TiO2NPs) have emerged as leading candidates for diverse biomedical applications. The present work emphasizes characterization along with synthesis of Ag-doped TiO2NPs, which possess tuneable physical properties. Titanium isopropoxide or silver nitrate have been utilized as precursors for production of pure and Ag-doped TiO2NPs by co-precipitation approach. The as synthesised pure and Ag doped TiO2NPs (3%,5% and 7% Ag doped) were subjected to characterisation via FTIR (Fourier Transform Infrared Spectroscopy), X-ray diffraction (XRD), SEM (Scanning Electron Microscopy), Energy Dispersive X-ray Spectroscopy (EDAX), UV-Vis (UV-visible diffuse Reflectance Spectroscopy). XRD spectra confirmed the anatase phase of TiO2NPs.UV-Visible spectral analysis revealed that with increasing doping concentration, the bandgap energy decreased progressively. The synthesized samples’ morphology was analyzed by SEM. EDAX analysis confirmed doping. FTIR studies established existence of diverse functional groups in TiO2NPs.The in vitro anticancer effect determination in human cancer cell line A549 was evaluated utilizing MTT assay method. From the study, it was found that 7% Ag doped TiO2 showed the lowest LC₅₀ value of 106.4 µg/mL, indicating enhanced anti-proliferative activity.