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<p>In this paper, a junctionless FET-based biosensor tailored for the detection of various biomolecules such as Carbohydrates, MCF10A (Healthy cells), Protein, Biotin, and SARS COV-2 has been simulated. This research presents a method of electrical detection using the label-free technique for detecting the biomolecules using a junctionless FET (JLFET), which offers very high sensitivity and real-time capabilities for detecting key components of the biomolecules, namely its permittivity and charge density. The inherent simplicity of JLFET fabrication and its enhanced gate controllability make this device structure a leading candidate for this application. To initiate detection, the biomolecules must first be confined within the etched nanocavities positioned under the gate electrodes. Presently, biomolecule detection relies on calibrated alterations in the device’s electrical characteristics following the immobilization of biomolecules in the cavity etched. This study concurrently considers the charge of biomolecules and their dielectric properties. The sensitivity analysis includes parameters such as <InlineEquation ID="IEq1"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="339_2025_8840_Article_IEq1.gif" Format="GIF" Height="16" Rendition="HTML" Resolution="72" Type="Linedraw" Width="45" /> </InlineMediaObject> <EquationSource Format="TEX">\(\Delta V_{TH}\)</EquationSource> </InlineEquation>, <InlineEquation ID="IEq2"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="339_2025_8840_Article_IEq2.gif" Format="GIF" Height="16" Rendition="HTML" Resolution="72" Type="Linedraw" Width="43" /> </InlineMediaObject> <EquationSource Format="TEX">\(\Delta I_{ON}\)</EquationSource> </InlineEquation>, <InlineEquation ID="IEq3"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="339_2025_8840_Article_IEq3.gif" Format="GIF" Height="17" Rendition="HTML" Resolution="72" Type="Linedraw" Width="35" /> </InlineMediaObject> <EquationSource Format="TEX">\(\Delta g_m\)</EquationSource> </InlineEquation>, and subthreshold slope. The proposed biosensor demonstrates a highly sensitive, rapid, reliable, cost-effective, and label-free biosensor with a sensitivity of 1V change in threshold voltage for <InlineEquation ID="IEq4"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="339_2025_8840_Article_IEq4.gif" Format="GIF" Height="10" Rendition="HTML" Resolution="72" Type="Linedraw" Width="13" /> </InlineMediaObject> <EquationSource Format="TEX">\(\kappa\)</EquationSource> </InlineEquation> = 4.1 (dielectric constant/ permittivity). This innovative structure holds promise for in-vivo biospecies diagnostics and array-based screening applications.</p>

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Dual Nano-cavity embedded Junctionless FET based biosensor with enhanced sensitivity

  • 期刊论文

  • 发表日期：

    2025年8月20日

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  • Kumari Nibha Priyadarshani

摘要

In this paper, a junctionless FET-based biosensor tailored for the detection of various biomolecules such as Carbohydrates, MCF10A (Healthy cells), Protein, Biotin, and SARS COV-2 has been simulated. This research presents a method of electrical detection using the label-free technique for detecting the biomolecules using a junctionless FET (JLFET), which offers very high sensitivity and real-time capabilities for detecting key components of the biomolecules, namely its permittivity and charge density. The inherent simplicity of JLFET fabrication and its enhanced gate controllability make this device structure a leading candidate for this application. To initiate detection, the biomolecules must first be confined within the etched nanocavities positioned under the gate electrodes. Presently, biomolecule detection relies on calibrated alterations in the device’s electrical characteristics following the immobilization of biomolecules in the cavity etched. This study concurrently considers the charge of biomolecules and their dielectric properties. The sensitivity analysis includes parameters such as \(\Delta V_{TH}\) , \(\Delta I_{ON}\) , \(\Delta g_m\) , and subthreshold slope. The proposed biosensor demonstrates a highly sensitive, rapid, reliable, cost-effective, and label-free biosensor with a sensitivity of 1V change in threshold voltage for \(\kappa\) = 4.1 (dielectric constant/ permittivity). This innovative structure holds promise for in-vivo biospecies diagnostics and array-based screening applications.