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<p>Traditional treatments for microbial infections often have adverse effects and consequences, while chemically synthesized nanoparticles can produce harmful by-products. This study employed a green synthesis approach to produce zinc-silver bimetallic nanoparticles (Zn-Ag BMNPs) using the leaf extract of <i>Tinospora cordifolia</i> (TC). Characterization of the synthesized ZnNPs and Zn-Ag BMNPs revealed diverse structural and functional properties. FTIR analysis of these samples confirmed the anchoring of pytochmical groups on the surface of BMNPs, while XRD pattern revealed structural details with a crystallite size of approximately 19&#xa0;nm. UV–Vis spectroscopy confirmed the formation of Zn-Ag BMNPs with absorption peaks in the range of 250–450&#xa0;nm, and the optical energy gap was measured as 3.1&#xa0;eV using Tauc plot analysis. Stability in aqueous suspensions was supported by zeta potential values of – 20.5&#xa0;mV and – 22.7&#xa0;mV, suggesting minimal aggregation. The potential antibacterial efficacy was assessed using disk diffusion and minimum inhibitory concentration (MIC) assays against <i>Escherichia coli</i> (<i>E. coli</i>). Zn-Ag BMNPs exhibited superior antimicrobial properties, achieving a maximum inhibition zone of 4&#xa0;mm at optimal concentrations, while ZnNPs displayed comparatively weaker activity. These findings suggest that synthesized Zn-Ag BMNPs nanocomposites may have significant senergetic effect in treating chronic diseases and addressing the aforementioned issues.</p>

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Bimetallic zinc-silver nanocomposites for superior antimicrobial efficacy

  • 期刊论文

  • 发表日期：

    2025年1月31日

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  • Naveen Kumar Madipoju,
  • Sarvani Jowhar Khanam,
  • Greeshma Sunkari,
  • Sai Madhuri Vasamsetti,
  • Vangala Divyasri,
  • Vijay Morampudi,
  • Ramu Naidu Savu,
  • Murali Banavoth,
  • Sreenivas Banne,
  • Imran Hasan,
  • Parvathalu Kalakonda

摘要

Traditional treatments for microbial infections often have adverse effects and consequences, while chemically synthesized nanoparticles can produce harmful by-products. This study employed a green synthesis approach to produce zinc-silver bimetallic nanoparticles (Zn-Ag BMNPs) using the leaf extract of Tinospora cordifolia (TC). Characterization of the synthesized ZnNPs and Zn-Ag BMNPs revealed diverse structural and functional properties. FTIR analysis of these samples confirmed the anchoring of pytochmical groups on the surface of BMNPs, while XRD pattern revealed structural details with a crystallite size of approximately 19 nm. UV–Vis spectroscopy confirmed the formation of Zn-Ag BMNPs with absorption peaks in the range of 250–450 nm, and the optical energy gap was measured as 3.1 eV using Tauc plot analysis. Stability in aqueous suspensions was supported by zeta potential values of – 20.5 mV and – 22.7 mV, suggesting minimal aggregation. The potential antibacterial efficacy was assessed using disk diffusion and minimum inhibitory concentration (MIC) assays against Escherichia coli (E. coli). Zn-Ag BMNPs exhibited superior antimicrobial properties, achieving a maximum inhibition zone of 4 mm at optimal concentrations, while ZnNPs displayed comparatively weaker activity. These findings suggest that synthesized Zn-Ag BMNPs nanocomposites may have significant senergetic effect in treating chronic diseases and addressing the aforementioned issues.