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<p>The objective of the present study is to develop a novel nanocomposite platform for drug delivery, and photothermal therapy. Molybdenum disulfide (MoS<sub>2</sub>) nanosheet, as one of the most stable transitional metal dichalcogenides, indicates unique structure, thermal, and optical properties. In this work, MFC nanocomposite was synthesized from MoS<sub>2</sub> nanosheets, iron oxide (Fe<sub>3</sub>O<sub>4</sub>) nanoparticles, and copper monosulfide (CuS) nanoparticles. Then structural, morphology, and optical properties of the nanocomposite were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), fourier transform infrared (FTIR), and ultraviolet-visible (UV-Vis) spectroscopies. After that, a photothermal experiment was done for the MFC nanocomposite with different concentrations (50, 100, 150, 200, and 400 ppm). Photothermal experiments indicated that nanocomposite with the concentration of 400 ppm have produced the highest photothermal heat (58.3<InlineEquation ID="IEq1"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="339_2024_8202_Article_IEq1.gif" Format="GIF" Height="14" Rendition="HTML" Resolution="72" Type="Linedraw" Width="9" /> </InlineMediaObject> <EquationSource Format="TEX">\(\:℃\:\)</EquationSource> </InlineEquation>) after 10&#xa0;min near infrared (NIR) laser irradiation. Then, a doxorubicin (DOX) drug was loaded into the nanocomposite. It was further studied for in-vitro DOX release with, and without laser irradiation. Results indicated that in the presence of NIR laser irradiation (1&#xa0;W/cm<sup>2</sup>), the optimized DOX/MFC nanocomposite show a controlled drug release of 63.5% in pH = 5.8 after 4&#xa0;h. Finally, the cytotoxicity of MFC nanocomposite on Hela cells was assessed using an MTT assay. The result of the MTT assay shows that 69.9% of Hela cells were killed by the nanocomposite at the concentration of 400&#xa0;µg/mL, and under an 808&#xa0;nm laser irradiation. Finally, a DOX drug was loaded in the nanocomposite with different concentrations. Results illustrated that in the presence of NIR- laser radiation (1&#xa0;W/cm<sup>2</sup>) cells viability were decreased when DOX concentration was increased in the nanocomposite. Therefore, the MFC nanocomposite at the concentration of 400 ppm was suggested as a good candidate in photothermal therapy, and drug delivery.</p>

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Investigation of structure, optical, and photothermal properties in MoS2/Fe3O4/CuS nanocomposite for doxorubicin delivery

  • 期刊论文

  • 发表日期：

    2025年1月6日

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  • Maryam Mahmoodabadi,
  • Mohammad Taghi Goodarzi,
  • Nasrin Salehi,
  • Alireza Jalali,
  • Ehsan Zahedi

摘要

The objective of the present study is to develop a novel nanocomposite platform for drug delivery, and photothermal therapy. Molybdenum disulfide (MoS2) nanosheet, as one of the most stable transitional metal dichalcogenides, indicates unique structure, thermal, and optical properties. In this work, MFC nanocomposite was synthesized from MoS2 nanosheets, iron oxide (Fe3O4) nanoparticles, and copper monosulfide (CuS) nanoparticles. Then structural, morphology, and optical properties of the nanocomposite were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), fourier transform infrared (FTIR), and ultraviolet-visible (UV-Vis) spectroscopies. After that, a photothermal experiment was done for the MFC nanocomposite with different concentrations (50, 100, 150, 200, and 400 ppm). Photothermal experiments indicated that nanocomposite with the concentration of 400 ppm have produced the highest photothermal heat (58.3 \(\:℃\:\) ) after 10 min near infrared (NIR) laser irradiation. Then, a doxorubicin (DOX) drug was loaded into the nanocomposite. It was further studied for in-vitro DOX release with, and without laser irradiation. Results indicated that in the presence of NIR laser irradiation (1 W/cm2), the optimized DOX/MFC nanocomposite show a controlled drug release of 63.5% in pH = 5.8 after 4 h. Finally, the cytotoxicity of MFC nanocomposite on Hela cells was assessed using an MTT assay. The result of the MTT assay shows that 69.9% of Hela cells were killed by the nanocomposite at the concentration of 400 µg/mL, and under an 808 nm laser irradiation. Finally, a DOX drug was loaded in the nanocomposite with different concentrations. Results illustrated that in the presence of NIR- laser radiation (1 W/cm2) cells viability were decreased when DOX concentration was increased in the nanocomposite. Therefore, the MFC nanocomposite at the concentration of 400 ppm was suggested as a good candidate in photothermal therapy, and drug delivery.