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<p>Mouse models have played a critical role in complementing human genetics research due to their genetic similarity to humans and well-annotated and tractable genome. For over 15&#xa0;years, the Diversity Outbred (DO) mice have existed as a powerful tool for mapping complex traits. With eight founder strains contributing to high levels of genetic diversity, heterozygosity, and large numbers of recombination events, DO mice allow for high-resolution genetic mapping. DO mice have been used to dissect the genetic architecture of physiological traits like blood lipids, behavioral traits such as cocaine self-administration, and molecular phenotypes such as gene expression across various tissues. Here we aim to exhaustively catalog DO mouse studies over the last 15&#xa0;years, including both mapping and non-mapping studies, as well as to provide an overview of software tools and online resources related to the model.</p>

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Fifteen years of the Diversity Outbred mouse model: a review

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月28日

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  • Zachary Tatom,
  • Michael F. Miles,
  • Abraham A. Palmer

摘要

Mouse models have played a critical role in complementing human genetics research due to their genetic similarity to humans and well-annotated and tractable genome. For over 15 years, the Diversity Outbred (DO) mice have existed as a powerful tool for mapping complex traits. With eight founder strains contributing to high levels of genetic diversity, heterozygosity, and large numbers of recombination events, DO mice allow for high-resolution genetic mapping. DO mice have been used to dissect the genetic architecture of physiological traits like blood lipids, behavioral traits such as cocaine self-administration, and molecular phenotypes such as gene expression across various tissues. Here we aim to exhaustively catalog DO mouse studies over the last 15 years, including both mapping and non-mapping studies, as well as to provide an overview of software tools and online resources related to the model.