Objectives To assess the effects of a bisacodyl micro-enema on rectal physio-morphology, image quality, and patient acceptance when used as preparation before MRI of rectal tumors. Materials and methods In this prospective single-center study, we made an intra-individual comparison of patients with suspected early rectal cancer who all completed MRI without (MRex) and with (MRin) a bisacodyl micro-enema. The width and the anal-oral extension of the submucosal edema in the healthy rectal wall, anal-oral extension of luminal fluid, and rectal distension were registered. Image artifacts were recorded with a figurative visual analog scale (fVAS), and patient acceptance with questionnaires at baseline, after MRex, and MRin. Significance levels were calculated with a t-test, the Wilcoxon signed-rank test, or McNemar’s test for paired samples and inter-reader agreement with Gwets AC1 statistics. Results Consecutively, 50 patients (mean age, 65 years ± 10, 26 men) were included. The median (iqr) summed width of submucosa (MRex, 26 (12) mm, MRin 39 (13) mm, p < 0.01) and anal-oral fluid extension (MRex 0 (0) mm, MRin 134 (91) mm, p < 0.001) increased. Susceptibility artifacts on diffusion weighted imaging (axial plane p ≤ 0.04 and parallel plane p < 0.001) were reduced. No increase in rectal distension, motion artifacts, or side effects was registered, and the patient-reported acceptance remained unchanged. Conclusion Bisacodyl significantly increased the submucosal width and extension of intraluminal fluid, did not lead to distension of the rectum, improved image quality, and was well tolerated by the patients. Key Points <Emphasis Type="BoldItalic">Question</Emphasis> Bisacodyl micro-enema can improve MRI of early stage-rectal tumors, but the impact on rectal physio-morphology, image quality, and patient acceptance is unknown. <Emphasis Type="BoldItalic">Result</Emphasis> Bisacodyl micro-enema increased the submucosal width and intraluminal fluid, did not distend the rectum, improved image quality, and was well tolerated by the patients. <Emphasis Type="BoldItalic">Clinical relevance</Emphasis> Bisacodyl micro-enema represents a reliable preparation before MRI of rectal tumors and can improve imaging of early-stage cancer. This is increasingly important because of the shift toward earlier stages due to screening programs and the growing use of organ-saving treatment. Graphical Abstract

Bisacodyl micro-enema before MRI of rectal tumors: effects on rectum, image quality and patient acceptance

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2025年9月17日

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Ellen Viktil,
Bettina Andrea Hanekamp,
Arild Nesbakken,
Ole Helmer Sjo,
Anne Negård,
Johann Baptist Dormagen,
Anselm Schulz

摘要

Objectives

To assess the effects of a bisacodyl micro-enema on rectal physio-morphology, image quality, and patient acceptance when used as preparation before MRI of rectal tumors.

Materials and methods

In this prospective single-center study, we made an intra-individual comparison of patients with suspected early rectal cancer who all completed MRI without (MRex) and with (MRin) a bisacodyl micro-enema. The width and the anal-oral extension of the submucosal edema in the healthy rectal wall, anal-oral extension of luminal fluid, and rectal distension were registered. Image artifacts were recorded with a figurative visual analog scale (fVAS), and patient acceptance with questionnaires at baseline, after MRex, and MRin. Significance levels were calculated with a t-test, the Wilcoxon signed-rank test, or McNemar’s test for paired samples and inter-reader agreement with Gwets AC1 statistics.

Results

Consecutively, 50 patients (mean age, 65 years ± 10, 26 men) were included. The median (iqr) summed width of submucosa (MRex, 26 (12) mm, MRin 39 (13) mm, p < 0.01) and anal-oral fluid extension (MRex 0 (0) mm, MRin 134 (91) mm, p < 0.001) increased. Susceptibility artifacts on diffusion weighted imaging (axial plane p ≤ 0.04 and parallel plane p < 0.001) were reduced. No increase in rectal distension, motion artifacts, or side effects was registered, and the patient-reported acceptance remained unchanged.

Conclusion

Bisacodyl significantly increased the submucosal width and extension of intraluminal fluid, did not lead to distension of the rectum, improved image quality, and was well tolerated by the patients.

Key Points

Question Bisacodyl micro-enema can improve MRI of early stage-rectal tumors, but the impact on rectal physio-morphology, image quality, and patient acceptance is unknown.

Result Bisacodyl micro-enema increased the submucosal width and intraluminal fluid, did not distend the rectum, improved image quality, and was well tolerated by the patients.

Clinical relevance Bisacodyl micro-enema represents a reliable preparation before MRI of rectal tumors and can improve imaging of early-stage cancer. This is increasingly important because of the shift toward earlier stages due to screening programs and the growing use of organ-saving treatment.

Graphical Abstract