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Objectives <p>To develop and validate a deep learning model based on three-dimensional features (DL_3D) for distinguishing lung adenocarcinoma (LUAD) from tuberculoma (TBM).</p> Materials and methods <p>A total of 1160 patients were collected from three hospitals. A vision transformer network-based DL_3D model was trained, and its performance in differentiating LUAD from TBM was evaluated using validation and external test sets. The performance of the DL_3D model was compared with that of two-dimensional features (DL_2D), radiomics, and six radiologists. Diagnostic performance was assessed using the area under the receiver operating characteristic curves (AUCs) analysis.</p> Results <p>The study included 840 patients in the training set (mean age, 54.8 years [range, 19–86 years]; 514 men), 210 patients in the validation set (mean age, 54.3 years [range, 18–86 years]; 128 men), and 110 patients in the external test set (mean age, 54.7 years [range, 22–88 years]; 51 men). In both the validation and external test sets, DL_3D exhibited excellent diagnostic performance (AUCs, 0.895 and 0.913, respectively). In the test set, the DL_3D model showed better performance (AUC, 0.913; 95% CI: 0.854, 0.973) than the DL_2D (AUC, 0.804, 95% CI: 0.722, 0.886; <i>p</i> &lt; 0.001), radiomics (AUC, 0.676, 95% CI: 0.574, 0.777; <i>p</i> &lt; 0.001), and six radiologists (AUCs, 0.692 to 0.810; <i>p</i> value range &lt; 0.001–0.035).</p> Conclusion <p>The DL_3D model outperforms expert radiologists in distinguishing LUAD from TBM.</p> Key Points <p><Emphasis Type="BoldItalic">Question</Emphasis> <i>Can a deep learning model perform in differentiating LUAD from TBM on non-enhanced CT images</i>?</p> <p><Emphasis Type="BoldItalic">Findings</Emphasis> <i>The DL_3D model demonstrated higher diagnostic performance than the DL_2D model, radiomics model, and six radiologists in differentiating LUAD and TBM</i>.</p> <p><Emphasis Type="BoldItalic">Clinical relevance</Emphasis> <i>The DL_3D model could accurately differentiate between LUAD and TBM, which can help clinicians make personalized treatment plans</i>.</p> Graphical Abstract <p></p>

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Non-enhanced CT deep learning model for differentiating lung adenocarcinoma from tuberculoma: a multicenter diagnostic study

  • 期刊论文

  • 发表日期：

    2025年6月11日

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  • Guojin Zhang,
  • Lan Shang,
  • Shenglin Li,
  • Jing Zhang,
  • Zhuoli Zhang,
  • Xin Zhang,
  • Rong Qian,
  • Ke Yang,
  • Xin Li,
  • Yiming Liu,
  • Ying Wu,
  • Hong Pu,
  • Yuntai Cao,
  • Qiong Man,
  • Weifang Kong

摘要

Objectives

To develop and validate a deep learning model based on three-dimensional features (DL_3D) for distinguishing lung adenocarcinoma (LUAD) from tuberculoma (TBM).

Materials and methods

A total of 1160 patients were collected from three hospitals. A vision transformer network-based DL_3D model was trained, and its performance in differentiating LUAD from TBM was evaluated using validation and external test sets. The performance of the DL_3D model was compared with that of two-dimensional features (DL_2D), radiomics, and six radiologists. Diagnostic performance was assessed using the area under the receiver operating characteristic curves (AUCs) analysis.

Results

The study included 840 patients in the training set (mean age, 54.8 years [range, 19–86 years]; 514 men), 210 patients in the validation set (mean age, 54.3 years [range, 18–86 years]; 128 men), and 110 patients in the external test set (mean age, 54.7 years [range, 22–88 years]; 51 men). In both the validation and external test sets, DL_3D exhibited excellent diagnostic performance (AUCs, 0.895 and 0.913, respectively). In the test set, the DL_3D model showed better performance (AUC, 0.913; 95% CI: 0.854, 0.973) than the DL_2D (AUC, 0.804, 95% CI: 0.722, 0.886; p < 0.001), radiomics (AUC, 0.676, 95% CI: 0.574, 0.777; p < 0.001), and six radiologists (AUCs, 0.692 to 0.810; p value range < 0.001–0.035).

Conclusion

The DL_3D model outperforms expert radiologists in distinguishing LUAD from TBM.

Key Points

Question Can a deep learning model perform in differentiating LUAD from TBM on non-enhanced CT images?

Findings The DL_3D model demonstrated higher diagnostic performance than the DL_2D model, radiomics model, and six radiologists in differentiating LUAD and TBM.

Clinical relevance The DL_3D model could accurately differentiate between LUAD and TBM, which can help clinicians make personalized treatment plans.

Graphical Abstract