Objectives Genicular artery embolization (GAE) is an emerging, minimally invasive treatment option for knee OA (osteoarthritis). The purpose of this study was to analyze factors associated with clinical success in GAE. Materials and Methods This IRB-approved, retrospective, single-center study analyzed 236 patients who underwent GAE for knee OA between May 2018 and September 2022. Clinical, radiographic, and technical variables were analyzed for association with clinical outcomes in GAE. The primary endpoint was clinical success assessed at one year. Results Overall clinical success was reported in 128 patients (54.2%). Clinical success was observed in younger patients (67.5 ± 9.4 vs 71.5 ± 11.1 years, p < 0.01) with higher BMI (29.7 ± 5.3 vs 27.6 ± 6.4 kg/m2, p < 0.01). Lower KL grade (2.8 ± 0.8 vs 3.2 ± 0.8, p < 0.01), OARSI medial joint space narrowing grade < 3 (77.9% vs 63.6%, p < 0.01), and sparing of the descending genicular artery (53.9% vs 35.2%, p < 0.01) were associated with clinical success. Factors correlated with clinical success in multivariate logistic regression included: BMI (OR = 1.1, p = 0.03), KL grade (OR = 0.6, p < 0.01), and sparing of the descending genicular artery (OR = 2.4, p < 0.01). Conclusion GAE is an effective procedure with durable clinical improvement at one year, particularly in younger patients and those with mild-to-moderate knee osteoarthritis. These findings suggest that early intervention with GAE may be appropriate in patients who are not candidates for, or do not desire, total knee arthroplasty. Key Points <Emphasis Type="BoldItalic">Question</Emphasis> GAE is a minimally invasive intervention for knee osteoarthritis, however, there is a paucity of evidence describing factors associated with improved clinical outcomes. <Emphasis Type="BoldItalic">Findings</Emphasis> Factors associated with clinical success in GAE included younger patients and those with early-stage osteoarthritis. <Emphasis Type="BoldItalic">Clinical relevance</Emphasis> These findings support GAE as an early intervention for patients with symptomatic knee osteoarthritis. Graphical Abstract

Early intervention in knee osteoarthritis with genicular artery embolization is associated with improved clinical outcomes

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2025年5月29日

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Tyler Callese,
Lucas R. Cusumano,
Hiro Sparks,
Kara Masterson,
Scott Genshaft,
Jessica K. Stewart,
Siddharth A. Padia

摘要

Objectives

Genicular artery embolization (GAE) is an emerging, minimally invasive treatment option for knee OA (osteoarthritis). The purpose of this study was to analyze factors associated with clinical success in GAE.

Materials and Methods

This IRB-approved, retrospective, single-center study analyzed 236 patients who underwent GAE for knee OA between May 2018 and September 2022. Clinical, radiographic, and technical variables were analyzed for association with clinical outcomes in GAE. The primary endpoint was clinical success assessed at one year.

Results

Overall clinical success was reported in 128 patients (54.2%). Clinical success was observed in younger patients (67.5 ± 9.4 vs 71.5 ± 11.1 years, p < 0.01) with higher BMI (29.7 ± 5.3 vs 27.6 ± 6.4 kg/m², p < 0.01). Lower KL grade (2.8 ± 0.8 vs 3.2 ± 0.8, p < 0.01), OARSI medial joint space narrowing grade < 3 (77.9% vs 63.6%, p < 0.01), and sparing of the descending genicular artery (53.9% vs 35.2%, p < 0.01) were associated with clinical success. Factors correlated with clinical success in multivariate logistic regression included: BMI (OR = 1.1, p = 0.03), KL grade (OR = 0.6, p < 0.01), and sparing of the descending genicular artery (OR = 2.4, p < 0.01).

Conclusion

GAE is an effective procedure with durable clinical improvement at one year, particularly in younger patients and those with mild-to-moderate knee osteoarthritis. These findings suggest that early intervention with GAE may be appropriate in patients who are not candidates for, or do not desire, total knee arthroplasty.

Key Points

Question GAE is a minimally invasive intervention for knee osteoarthritis, however, there is a paucity of evidence describing factors associated with improved clinical outcomes.

Findings Factors associated with clinical success in GAE included younger patients and those with early-stage osteoarthritis.

Clinical relevance These findings support GAE as an early intervention for patients with symptomatic knee osteoarthritis.

Graphical Abstract