Objective To assess qualitative and quantitative imaging features, including lesion-to-liver contrast enhancement ratio (LLCER), on gadoxetic acid-enhanced MRI for differentiating atypical focal nodular hyperplasia (aFNH) from hepatocellular adenoma (HCA) subtypes. Materials and methods This retrospective study included patients with histopathologically-confirmed aFNH and HCA who underwent gadoxetic acid-enhanced MRI between January 2010 and December 2020. Two radiologists assessed qualitative imaging features and calculated LLCERs for quantitative evaluation of HBP enhancement. Statistical analyses included ROC curves, sensitivity, specificity, and a decision tree. Results 86 patients (41 ± 11 years; 64 women) had 29 aFNHs and 90 HCAs. HBP iso-/hyperintensity was observed in 72.4% (21/29) of aFNH compared to 28.8% (15/52) of U-HCA, 35% (7/20) of I-HCA, and 0% (0/11) of H-HCA. β-HCA showed 71.4% (5/7) iso-/hyperintensity, overlapping with aFNH (p = 0.17). Homogeneous iso-/hyperintensity and rim-like enhancement were present in 48.3% (14/29) and 20.7% (6/29) of aFNH but absent in β-HCA (p = 0.004). LLCER demonstrated high diagnostic performance, differentiating aFNH from U-HCA, H-HCA, and I-HCA(AUCs 0.91–0.99, sensitivities 82.8–96.6%, specificities 90.0–100%). For β-HCA, LLCER showed overlap with aFNH; AUCs (0.62–0.64) and specificities (57.1%). Among HCAs with HBP iso-/hyperintensity, 74.1% had negative LLCER values, while 25.9% (mostly β-HCA/U-HCA) showed positive values (true enhancement). Combined decision trees selected LLCER as the primary node, with downstream HBP features variably incorporated, except β-HCA, which solely used qualitative features. Conclusion HBP iso-/hyperintensity and LLCER reliably differentiated aFNH from most HCA subtypes, except β-HCA, validated by decision tree analyses. Homogeneous iso-/hyperintensity or rim-like enhancement was absent in β-HCA, aiding differentiation. Key Points <Emphasis Type="BoldItalic">Question</Emphasis> Variability in hepatobiliary phase (HBP) enhancement among hepatocellular adenoma (HCA) subtypes and atypical FNH (aFNH) poses diagnostic challenges. <Emphasis Type="BoldItalic">Findings</Emphasis> Despite HBP enhancement overlap in aFNH/β-HCA, “homogeneous” and rim-like enhancement aided aFNH differentiation from HCAs. LLCER separated HCAs lacking true HBP uptake from aFNH. <Emphasis Type="BoldItalic">Clinical relevance</Emphasis> This study explored challenges in differentiating aFNH from HCA subtypes, especially overlapping β-HCA, highlighting discriminatory qualitative markers and quantitative assessment to distinguish true HBP enhancement, an approach validated by decision tree analysis. Graphical Abstract

Qualitative and quantitative assessment of gadoxetic acid MRI in distinguishing atypical focal nodular hyperplasia from hepatocellular adenoma subtypes

期刊论文
发表日期：

2025年5月14日

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Khaled Y. Elbanna,
Korosh Khalili,
May AlMoharb,
Ankur Goel,
Sandra Fischer,
Tae Kyoung Kim

摘要

Objective

To assess qualitative and quantitative imaging features, including lesion-to-liver contrast enhancement ratio (LLCER), on gadoxetic acid-enhanced MRI for differentiating atypical focal nodular hyperplasia (aFNH) from hepatocellular adenoma (HCA) subtypes.

Materials and methods

This retrospective study included patients with histopathologically-confirmed aFNH and HCA who underwent gadoxetic acid-enhanced MRI between January 2010 and December 2020. Two radiologists assessed qualitative imaging features and calculated LLCERs for quantitative evaluation of HBP enhancement. Statistical analyses included ROC curves, sensitivity, specificity, and a decision tree.

Results

86 patients (41 ± 11 years; 64 women) had 29 aFNHs and 90 HCAs. HBP iso-/hyperintensity was observed in 72.4% (21/29) of aFNH compared to 28.8% (15/52) of U-HCA, 35% (7/20) of I-HCA, and 0% (0/11) of H-HCA. β-HCA showed 71.4% (5/7) iso-/hyperintensity, overlapping with aFNH (p = 0.17). Homogeneous iso-/hyperintensity and rim-like enhancement were present in 48.3% (14/29) and 20.7% (6/29) of aFNH but absent in β-HCA (p = 0.004). LLCER demonstrated high diagnostic performance, differentiating aFNH from U-HCA, H-HCA, and I-HCA(AUCs 0.91–0.99, sensitivities 82.8–96.6%, specificities 90.0–100%). For β-HCA, LLCER showed overlap with aFNH; AUCs (0.62–0.64) and specificities (57.1%). Among HCAs with HBP iso-/hyperintensity, 74.1% had negative LLCER values, while 25.9% (mostly β-HCA/U-HCA) showed positive values (true enhancement). Combined decision trees selected LLCER as the primary node, with downstream HBP features variably incorporated, except β-HCA, which solely used qualitative features.

Conclusion

HBP iso-/hyperintensity and LLCER reliably differentiated aFNH from most HCA subtypes, except β-HCA, validated by decision tree analyses. Homogeneous iso-/hyperintensity or rim-like enhancement was absent in β-HCA, aiding differentiation.

Key Points

Question Variability in hepatobiliary phase (HBP) enhancement among hepatocellular adenoma (HCA) subtypes and atypical FNH (aFNH) poses diagnostic challenges.

Findings Despite HBP enhancement overlap in aFNH/β-HCA, “homogeneous” and rim-like enhancement aided aFNH differentiation from HCAs. LLCER separated HCAs lacking true HBP uptake from aFNH.

Clinical relevance This study explored challenges in differentiating aFNH from HCA subtypes, especially overlapping β-HCA, highlighting discriminatory qualitative markers and quantitative assessment to distinguish true HBP enhancement, an approach validated by decision tree analysis.

Graphical Abstract