Objectives Investigate the impact of mammography device grouped by vendor on volumetric breast density and propose a method that mitigates biases when determining the proportion of high-density women. Materials and methods Density grade class and volumetric breast density distributions were obtained from mammographic images from three different vendor devices in different centers using breast density evaluation software in a retrospective study. Density distributions were compared across devices with a Mann–Whitney U test and breast density thresholds corresponding to distribution percentiles calculated. A method of matching density percentiles is proposed to determine women at potentially high risk while mitigating possible bias due to the device used for screening. Results 2083 (mean age 59 ± 5.4), 531 (mean age 58.8 ± 5.7) and 244 (mean age 60.7 ± 6.0) screened women were evaluated on three vendor devices, respectively. Both the density grade distribution and the volumetric breast density were different between Vendor 1 and Vendor 2 data (p < 0.001) and between Vendor 1 and Vendor 3 data (p < 0.001). Between Vendor 2 and Vendor 3, no significant difference was observed (p = 0.67 for density grade, p = 0.29 for volumetric density). To recruit the top 10% of women with extremely dense breasts required respective density thresholds of 16.1%, 13.6% and 13.8% for the three vendor devices. Conclusion Density grade class and volumetric breast density distributions differ between devices grouped by vendor and can result in statistically different breast density distributions. Percentile-dependent density thresholds can ensure unbiased selection of high-risk women. Key Points <Emphasis Type="BoldItalic">Question</Emphasis> Does the use of x-ray systems from different vendors influence breast density evaluation and the resulting selection of high-risk women during breast cancer screening? <Emphasis Type="BoldItalic">Findings</Emphasis> Statistically significant differences were observed between breast density distributions of different vendors; a method of matching via percentiles is proposed to prevent biased density evaluations. <Emphasis Type="BoldItalic">Clinical relevance</Emphasis> Measured breast density distributions differed between X-ray devices. A workaround is proposed that determines density thresholds corresponding to a specified population, allowing the same proportion of women to be selected with a density algorithm. Graphical Abstract

A practical work around for breast density distribution discrepancies between mammographic images from different vendors

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2025年1月31日

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Tobias Wagner,
Lesley Cockmartin,
Yao-Kuan Wang,
Nicholas Marshall,
Hilde Bosmans

摘要

Objectives

Investigate the impact of mammography device grouped by vendor on volumetric breast density and propose a method that mitigates biases when determining the proportion of high-density women.

Materials and methods

Density grade class and volumetric breast density distributions were obtained from mammographic images from three different vendor devices in different centers using breast density evaluation software in a retrospective study. Density distributions were compared across devices with a Mann–Whitney U test and breast density thresholds corresponding to distribution percentiles calculated. A method of matching density percentiles is proposed to determine women at potentially high risk while mitigating possible bias due to the device used for screening.

Results

2083 (mean age 59 ± 5.4), 531 (mean age 58.8 ± 5.7) and 244 (mean age 60.7 ± 6.0) screened women were evaluated on three vendor devices, respectively. Both the density grade distribution and the volumetric breast density were different between Vendor 1 and Vendor 2 data (p < 0.001) and between Vendor 1 and Vendor 3 data (p < 0.001). Between Vendor 2 and Vendor 3, no significant difference was observed (p = 0.67 for density grade, p = 0.29 for volumetric density). To recruit the top 10% of women with extremely dense breasts required respective density thresholds of 16.1%, 13.6% and 13.8% for the three vendor devices.

Conclusion

Density grade class and volumetric breast density distributions differ between devices grouped by vendor and can result in statistically different breast density distributions. Percentile-dependent density thresholds can ensure unbiased selection of high-risk women.

Key Points

Question Does the use of x-ray systems from different vendors influence breast density evaluation and the resulting selection of high-risk women during breast cancer screening?

Findings Statistically significant differences were observed between breast density distributions of different vendors; a method of matching via percentiles is proposed to prevent biased density evaluations.

Clinical relevance Measured breast density distributions differed between X-ray devices. A workaround is proposed that determines density thresholds corresponding to a specified population, allowing the same proportion of women to be selected with a density algorithm.

Graphical Abstract