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Objective <p>To estimate the developmental trends of quantitative parameters obtained from chest computed tomography (CT) and to provide normative values on dimensions of bronchi and arteries, as well as bronchus-artery (BA) ratios from preschool age to young adulthood.</p> Materials and methods <p>Two independent radiologists screened a dataset of 1160 chest CT scans, initially reported as normal, from participants aged 0 to 24 years. Using an automated deep learning-based algorithm, we computed the following bronchus and artery parameters: bronchial outer diameter (B<sub>out</sub>), bronchial inner diameter (B<sub>in</sub>), adjacent pulmonary artery diameter (A), bronchial wall thickness (B<sub>wt</sub>), bronchial wall area (B<sub>WA</sub>), and bronchial outer area (B<sub>OA</sub>). From these parameters, we computed the following ratios: B<sub>out</sub>/A, B<sub>in</sub>/A, B<sub>wt</sub>/A, B<sub>wt</sub>/B<sub>out</sub>, and B<sub>WA</sub>/B<sub>OA</sub>. Furthermore, mean lung density, total lung volume, and the square root of wall area of bronchi with a 10-mm lumen perimeter (Pi10) were obtained. The effects on CT parameters of age, sex, and iodine contrast were investigated using mixed-effects or regression model analyses.</p> Results <p>375 normal inspiratory chest CT scans (females / males = 156 / 219; mean age [SD] 12.7 [5.0] years) met the inclusion criteria. B<sub>out</sub> and B<sub>in</sub> progressively increased with age (all <i>p</i> &lt; 0.05), but B<sub>wt</sub>, B<sub>out</sub>/A, B<sub>in</sub>/A, B<sub>wt</sub>/A, B<sub>wt</sub>/B<sub>out</sub>, or B<sub>WA</sub>/B<sub>OA</sub> did not. Total lung volume and mean lung density continuously increased with age (both <i>p</i> &lt; 0.001), while Pi10 did not exhibit such a trend. B<sub>out</sub>, total lung volume, and mean lung density were the only parameters that differed between males and females, all higher in males than females (all <i>p</i> &lt; 0.03). The presence of iodinated contrast led to greater values for B<sub>wt</sub>, B<sub>wt</sub>/B<sub>out</sub>, and B<sub>WA</sub>/B<sub>OA</sub>, but lower values for B<sub>in</sub>, B<sub>out</sub>/A, B<sub>in</sub>/A, and B<sub>wt</sub>/A (all <i>p</i> &lt; 0.01).</p> Conclusion <p>Quantitative CT parameters of both lung parenchyma and bronchi exhibit growth-related changes, but from 6 to 24 years ratios between bronchus and artery dimensions remain constant. Contrast-enhanced CT scans affect the assessment of lung parenchyma and bronchial size. We propose age and technique-dependent normative values for bronchial dimensions and wall thickness.</p> Key Points <p><Emphasis Type="BoldItalic">Question</Emphasis> <i>What are the developmental trends of quantitative lung CT parameters in patients from childhood into young adulthood?</i></p> <p><Emphasis Type="BoldItalic">Findings</Emphasis> <i>The ratio between bronchus and pulmonary artery dimensions demonstrates consistent values across age groups, indicating synchronized growth between bronchi and paired pulmonary arteries.</i></p> <p><Emphasis Type="BoldItalic">Clinical relevance</Emphasis> <i>Our findings highlight the importance of standardized CT protocol and volume acquisition, and emphasize the need for ongoing collection of normal chest CT scans to refine the proposed reference values.</i></p>

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Normative values for lung, bronchial sizes, and bronchus-artery ratios in chest CT scans: from infancy into young adulthood

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月1日

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  • Qianting Lv,
  • Yuxin Chen,
  • Daan Caudri,
  • Eleni-Rosalina Andrinopoulou,
  • Wieying Kuo,
  • Jean-Paul Charbonnier,
  • Robert J. Fleck,
  • Luis Riera Soler,
  • Matteo Paoletti,
  • Francois Vermeulen,
  • Giovanni Morana,
  • Edward Y. Lee,
  • Marleen de Bruijne,
  • Harm A. W. M. Tiddens,
  • Pierluigi Ciet,
  • Lauren Akesson,
  • Silvia Bertolo,
  • Alan S. Brody,
  • Kris de Boeck,
  • Pim A. de Jong,
  • Robert J. Fleck,
  • Francesco Fraioli,
  • Pilar Garcia-Peña,
  • Silvia Gartner,
  • Anders Lindblad,
  • Michael McCartin,
  • Christian P. Mol,
  • Arlette E. Odink,
  • Stephen M. Stick

摘要

Objective

To estimate the developmental trends of quantitative parameters obtained from chest computed tomography (CT) and to provide normative values on dimensions of bronchi and arteries, as well as bronchus-artery (BA) ratios from preschool age to young adulthood.

Materials and methods

Two independent radiologists screened a dataset of 1160 chest CT scans, initially reported as normal, from participants aged 0 to 24 years. Using an automated deep learning-based algorithm, we computed the following bronchus and artery parameters: bronchial outer diameter (Bout), bronchial inner diameter (Bin), adjacent pulmonary artery diameter (A), bronchial wall thickness (Bwt), bronchial wall area (BWA), and bronchial outer area (BOA). From these parameters, we computed the following ratios: Bout/A, Bin/A, Bwt/A, Bwt/Bout, and BWA/BOA. Furthermore, mean lung density, total lung volume, and the square root of wall area of bronchi with a 10-mm lumen perimeter (Pi10) were obtained. The effects on CT parameters of age, sex, and iodine contrast were investigated using mixed-effects or regression model analyses.

Results

375 normal inspiratory chest CT scans (females / males = 156 / 219; mean age [SD] 12.7 [5.0] years) met the inclusion criteria. Bout and Bin progressively increased with age (all p < 0.05), but Bwt, Bout/A, Bin/A, Bwt/A, Bwt/Bout, or BWA/BOA did not. Total lung volume and mean lung density continuously increased with age (both p < 0.001), while Pi10 did not exhibit such a trend. Bout, total lung volume, and mean lung density were the only parameters that differed between males and females, all higher in males than females (all p < 0.03). The presence of iodinated contrast led to greater values for Bwt, Bwt/Bout, and BWA/BOA, but lower values for Bin, Bout/A, Bin/A, and Bwt/A (all p < 0.01).

Conclusion

Quantitative CT parameters of both lung parenchyma and bronchi exhibit growth-related changes, but from 6 to 24 years ratios between bronchus and artery dimensions remain constant. Contrast-enhanced CT scans affect the assessment of lung parenchyma and bronchial size. We propose age and technique-dependent normative values for bronchial dimensions and wall thickness.

Key Points

Question What are the developmental trends of quantitative lung CT parameters in patients from childhood into young adulthood?

Findings The ratio between bronchus and pulmonary artery dimensions demonstrates consistent values across age groups, indicating synchronized growth between bronchi and paired pulmonary arteries.

Clinical relevance Our findings highlight the importance of standardized CT protocol and volume acquisition, and emphasize the need for ongoing collection of normal chest CT scans to refine the proposed reference values.