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Key message <p>GAPDH regulates plant stem cell maintenance.</p> Abstract <p>WUSCHEL (WUS) and WUSCHEL-RELATED HOMEOBOX (WOX) family proteins are vital for maintaining the homeostasis of stem cells, which is necessary for the continuous growth and the development of plants. Plants frequently encounter environmental stress that can lead to an increase in reactive oxygen species, such as hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>). However, the exact ways in which plant stem cells sense and respond to H<sub>2</sub>O<sub>2</sub> signals remain unclear. This research indicates that cytosolic glyceraldehyde-3-phosphate dehydrogenase (GAPDH) helps regulate stem cell maintenance in Arabidopsis in response to H<sub>2</sub>O<sub>2</sub>. Hydrogen peroxide causes the relocation of two cytosolic GAPDH proteins, GAPC1 and GAPC2, from the cytoplasm to the nucleus. These isoforms interact with WUS/WOX proteins and modulate the expression of the <i>WUS/WOX</i> gene by binding to its promoter. When the expression of <i>GAPC1</i> and <i>GAPC2</i> is decreased, stem cell homeostasis and overall plant growth become more sensitive to H<sub>2</sub>O<sub>2</sub>. Thus, cytosolic GAPDH may serve as a sensor for H<sub>2</sub>O<sub>2</sub>, influencing the maintenance of plant stem cells under oxidative stress.</p>

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Cytosolic glyceraldehyde-3-phosphate dehydrogenase regulates plant stem cell maintenance under oxidative stress

  • 期刊论文

  • 发表日期：

    2025年5月13日

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  • Jiaqi Qiu,
  • Minghuang Chen,
  • Zheqi Cai,
  • Xiaofen Chen,
  • Zelong Pang,
  • Hao Chen,
  • Tao Huang

摘要

Key message

GAPDH regulates plant stem cell maintenance.

Abstract

WUSCHEL (WUS) and WUSCHEL-RELATED HOMEOBOX (WOX) family proteins are vital for maintaining the homeostasis of stem cells, which is necessary for the continuous growth and the development of plants. Plants frequently encounter environmental stress that can lead to an increase in reactive oxygen species, such as hydrogen peroxide (H2O2). However, the exact ways in which plant stem cells sense and respond to H2O2 signals remain unclear. This research indicates that cytosolic glyceraldehyde-3-phosphate dehydrogenase (GAPDH) helps regulate stem cell maintenance in Arabidopsis in response to H2O2. Hydrogen peroxide causes the relocation of two cytosolic GAPDH proteins, GAPC1 and GAPC2, from the cytoplasm to the nucleus. These isoforms interact with WUS/WOX proteins and modulate the expression of the WUS/WOX gene by binding to its promoter. When the expression of GAPC1 and GAPC2 is decreased, stem cell homeostasis and overall plant growth become more sensitive to H2O2. Thus, cytosolic GAPDH may serve as a sensor for H2O2, influencing the maintenance of plant stem cells under oxidative stress.