<p>Inflammatory rheumatic diseases (IRDs) present substantial risks of infection-related comorbidities during pregnancy. This study evaluates the knowledge, experience, and perceptions of healthcare professionals concerning the prevention of these risks. An international, cross-sectional survey was administered using the SurveyMonkey platform. The survey was disseminated to healthcare professionals specializing in rheumatology, obstetrics, infectious diseases, internal medicine, general practice, and related disciplines through social media channels. Developed in accordance with European Alliance of Associations for Rheumatology (EULAR) recommendations, this survey comprised 30 questions, including multiple-choice, Likert-type, and open-ended formats. A total of 201 healthcare professionals from thirty-six countries participated in the study, with rheumatologists comprising the majority (<i>n</i> = 145, 72.1%). Systemic lupus erythematosus (<i>n</i> = 183), systemic vasculitis (<i>n</i> = 141), and rheumatoid arthritis (<i>n</i> = 86) were identified as the diseases associated with the highest risk of infection-related comorbidities. The most frequently recommended infectious conditions for screening included Hepatitis B (<i>n</i> = 142), urinary tract infections (<i>n</i> = 141), and Hepatitis C (<i>n</i> = 129). The primary risk factors were uncontrolled disease activity (<i>n</i> = 176), high-dose corticosteroid use (<i>n</i> = 164), and high disease severity (<i>n</i> = 162). The most significant systemic barriers were insufficient number of specialists (<i>n</i> = 156), and absence of multidisciplinary teams (<i>n</i> = 155). This study identifies structural and educational deficiencies in the management of infection-related comorbidities among pregnant patients with IRD. The results underscore the need for targeted clinical guidelines, enhanced multidisciplinary care models, and expanded pre-pregnancy counseling.</p>