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<p>Sarcoidosis is a chronic granulomatous inflammatory disease that primarily affects the lungs and skin. Cutaneous involvement occurs in approximately 30% of cases. We report herewith a rare case of a 55-year-old man with chronic, non-healing bilateral leg ulcers, ultimately diagnosed as ulcerative cutaneous sarcoidosis through histopathological confirmation. Giant leg ulcers complicating systemic sarcoidosis is rare and its management is challenging because there are no specific recommendation. In our case, a 24-month course of intravenous infliximab associated with oral prednisone induced sustained clinical remission. The current decline is three years. The aim of our work is to review the clinical presentation and management of ulcerative cutaneous sarcoidosis and compare them to reported cases in literature.</p>

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Successful infliximab therapy in systemic sarcoidosis presenting with giant leg ulcers: a case based review

  • 期刊论文

  • 发表日期：

    2025年5月6日

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  • Nabil Belfeki,
  • Nadia Ghariani Fetoui,
  • Nour El Imene Ouni,
  • Juliette Avci,
  • Renaud Guedec-Ghelfi,
  • Sonia Kammoun,
  • Nouha Ghriss

摘要

Sarcoidosis is a chronic granulomatous inflammatory disease that primarily affects the lungs and skin. Cutaneous involvement occurs in approximately 30% of cases. We report herewith a rare case of a 55-year-old man with chronic, non-healing bilateral leg ulcers, ultimately diagnosed as ulcerative cutaneous sarcoidosis through histopathological confirmation. Giant leg ulcers complicating systemic sarcoidosis is rare and its management is challenging because there are no specific recommendation. In our case, a 24-month course of intravenous infliximab associated with oral prednisone induced sustained clinical remission. The current decline is three years. The aim of our work is to review the clinical presentation and management of ulcerative cutaneous sarcoidosis and compare them to reported cases in literature.