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<p>We report on a&#xa0;73-year-old patient with formerly diagnosed melanoma and newly recognized tumor formation within the larynx. In a&#xa0;frozen section specimen, there was no indication of malignancy. Differential diagnosis favored a&#xa0;granular cell tumor at first. Immunohistochemistry and histomorphology after tissue transfer into paraffin led to the diagnosis of adult rhabdomyoma. This case report examines the histomorphologic and immunhistochemic differential diagnosis of large-cell laryngeal lesions with special focus on the challenges associated with frozen section specimens.</p>

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Adultes Rhabdomyom

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月10日

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  • Marvin Seidel,
  • Martin Bredt,
  • Hans Kreipe,
  • Nora Schaumann

摘要

We report on a 73-year-old patient with formerly diagnosed melanoma and newly recognized tumor formation within the larynx. In a frozen section specimen, there was no indication of malignancy. Differential diagnosis favored a granular cell tumor at first. Immunohistochemistry and histomorphology after tissue transfer into paraffin led to the diagnosis of adult rhabdomyoma. This case report examines the histomorphologic and immunhistochemic differential diagnosis of large-cell laryngeal lesions with special focus on the challenges associated with frozen section specimens.