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Background <p>Besides reactions of the IgE-mediated immediate type, medicamentous therapies can cause a&#xa0;variety of different mucocutaneous adverse events. Exanthematous manifestations require a&#xa0;fast and certain diagnosis due to their extent, sometimes rapid progression, and mucous membrane or organ involvement.</p> Objectives <p>The spectrum of non-IgE-mediated exanthematic drug reactions is covered.</p> Material and methods <p>The most relevant reactions are portrayed clinically and histopathologically.</p> Results <p>Displayed are classical maculo-papular drug eruption, lichenoid drug reaction, acute generalized exanthematic pustulosis (AGEP), severe potentially life-threatening drug reactions such as Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) as well as generalized bullous fixed drug eruption (GBFDE), drug reaction with eosinophilia and systemic symptoms (DRESS), and some others.</p> Conclusions <p>Cutaneous drug-related side effects cover a&#xa0;broad spectrum. Important for the correct treatment is a&#xa0;reliable diagnosis. In the case of severe, life-threatening drug reactions, however, permanent discontinuation of the drug is essential.</p>

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Exanthematische Arzneimittelreaktionen

  • 期刊论文

  • 发表日期：

    2025年2月18日

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  • Mirjana Ziemer,
  • Elisabeth Livingstone

摘要

Background

Besides reactions of the IgE-mediated immediate type, medicamentous therapies can cause a variety of different mucocutaneous adverse events. Exanthematous manifestations require a fast and certain diagnosis due to their extent, sometimes rapid progression, and mucous membrane or organ involvement.

Objectives

The spectrum of non-IgE-mediated exanthematic drug reactions is covered.

Material and methods

The most relevant reactions are portrayed clinically and histopathologically.

Results

Displayed are classical maculo-papular drug eruption, lichenoid drug reaction, acute generalized exanthematic pustulosis (AGEP), severe potentially life-threatening drug reactions such as Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) as well as generalized bullous fixed drug eruption (GBFDE), drug reaction with eosinophilia and systemic symptoms (DRESS), and some others.

Conclusions

Cutaneous drug-related side effects cover a broad spectrum. Important for the correct treatment is a reliable diagnosis. In the case of severe, life-threatening drug reactions, however, permanent discontinuation of the drug is essential.