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<p>In this study, we design a novel, multi-functional system based on l-aspartic acid-Cu(II) metal–organic framework (Fe3O4@ Asp.Cu-MOFs) on a melamine-graphene oxide (GO-MA) coated with maltose carbon microspheres (GO-MA-Mt/Fe3O4@ Asp.Cu-MOFs) for pH-triggered&#xa0;release of doxorubicin (DOX) to A549 lung cancer cells. The chemical structure of the designed system was studied using techniques such as FT-IR, FE-SEM/EDX, VSM, XRD, BET, and Zeta potential. The&#xa0;DOX encapsulation efficiency&#xa0;was 95.79% with a loading capacity&#xa0;of 9.57%. The in vitro release of DOX from the GO-MA-Mt/Fe3O4@ Asp.Cu-MOFs further verified the system's controlled release and pH-sensitive features. Analysis of the DOX release mechanism from the GO-MA-Mt/Fe3O4@ Asp.Cu-MOFs system revealed that the Korsmeyer-Peppas model, which incorporates Fickian diffusion, best describes the release behavior of DOX. The relative biocompatibility and safety of the prepared GO-MA-Mt/Fe3O4@ Asp.Cu-MOFs were confirmed through the examination of their cellular cytotoxicity towards A549 cells. In contrast, the DOX-loaded GO-MA-Mt/Fe3O4@ Asp.Cu-MOFs exhibited elevated cytotoxic effects on A549 cells, resulting from the controlled DOX release and improved targeting&#xa0;ability towards these cells. The system's strong antioxidant property, blood compatibility, enhanced stability, and favorable biodegradation properties were verified through in vitro DPPH testing, hemolysis assays, colloidal stability assessments, and enzymatic degradation studies, respectively. Based on these results, the current study indicates that the designed GO-MA-Mt/Fe3O4@ Asp.Cu-MOFs could serve as a pH-sensitive system for regulated and targeted delivery of drugs in cancer therapy and other biomedical uses.</p>

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Development of a pH-targeted multi-functional system using a magnetic l-aspartic acid-Cu (II) MOFs coated on melamine-graphene oxide-maltose carbon microspheres for controlled release of doxorubicin

  • 期刊论文

  • 发表日期：

    2026年7月8日

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  • Soheyla Karimi,
  • Mehdi Rezaei Moghadam,
  • Hassan Namazi

摘要

In this study, we design a novel, multi-functional system based on l-aspartic acid-Cu(II) metal–organic framework (Fe3O4@ Asp.Cu-MOFs) on a melamine-graphene oxide (GO-MA) coated with maltose carbon microspheres (GO-MA-Mt/Fe3O4@ Asp.Cu-MOFs) for pH-triggered release of doxorubicin (DOX) to A549 lung cancer cells. The chemical structure of the designed system was studied using techniques such as FT-IR, FE-SEM/EDX, VSM, XRD, BET, and Zeta potential. The DOX encapsulation efficiency was 95.79% with a loading capacity of 9.57%. The in vitro release of DOX from the GO-MA-Mt/Fe3O4@ Asp.Cu-MOFs further verified the system's controlled release and pH-sensitive features. Analysis of the DOX release mechanism from the GO-MA-Mt/Fe3O4@ Asp.Cu-MOFs system revealed that the Korsmeyer-Peppas model, which incorporates Fickian diffusion, best describes the release behavior of DOX. The relative biocompatibility and safety of the prepared GO-MA-Mt/Fe3O4@ Asp.Cu-MOFs were confirmed through the examination of their cellular cytotoxicity towards A549 cells. In contrast, the DOX-loaded GO-MA-Mt/Fe3O4@ Asp.Cu-MOFs exhibited elevated cytotoxic effects on A549 cells, resulting from the controlled DOX release and improved targeting ability towards these cells. The system's strong antioxidant property, blood compatibility, enhanced stability, and favorable biodegradation properties were verified through in vitro DPPH testing, hemolysis assays, colloidal stability assessments, and enzymatic degradation studies, respectively. Based on these results, the current study indicates that the designed GO-MA-Mt/Fe3O4@ Asp.Cu-MOFs could serve as a pH-sensitive system for regulated and targeted delivery of drugs in cancer therapy and other biomedical uses.