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<p>Gum Odina, an arabinogalactan-rich polysaccharide from <i>Odina wodier</i>, shows a new era as a multifunctional biomaterial for smart pharmaceutical and biomedical applications. This review is a critical summarization of the quantitative and qualitative information available on the source, purification, physicochemical properties, modification strategies, dosage form performance, and tissue regeneration potential, which is one of the major problems in biomedical engineering, particularly in wounds, bone defects, and periodontal repair. The modified gum Odina was addressed as an all-round biomaterial for the formation of scaffolds and hydrogels according to these requirements. The swelling index, release kinetics, cell viability, and wound contraction were tabulated, and drug release and adsorption profiles were interpreted via zero-order, Higuchi, Korsmeyer-Peppas, Langmuir, and Freundlich models. Studies have systematically reported porosity 75–95%, swelling indices the range of 250–300% (more in pH 6.5-7 and controlled in 1.2-2 pH), drug entrapment efficiencies often more than 70% and longer drug release periods (up to 24&#xa0;h), removal efficiencies achieved for dyes &gt; 90%, in vitro cell viability values in the order of 90%, and in vivo results in terms of wound contraction of 98% for 18 days, hydroxyproline of 240 ug/100&#xa0;mg of tissue, enhanced collagen deposition, and accelerated re-epithelialization. Qualitative findings revealed the intrinsic biocompatibility, mucoadhesion, antioxidant and anti-inflammatory activity, prebiotic activity, and extracellular matrix-mimetic architecture of the scaffolds as crucial performance drivers. Altogether, the available evidence makes Odina gum a versatile, eco-friendly platform excipient and biomaterial for controlled drug delivery, therapeutic drugs directed towards the gut, wound healing, and tissue regeneration.</p> Graphical abstract <p></p>

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Modified gum odina as dynamic platform: from source to advanced drug delivery and tissue regeneration

  • 期刊论文

  • 发表日期：

    2026年5月6日

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  • Dhiman Roy,
  • Ushasi Das,
  • Adarsha Bachhar,
  • Shila Barman,
  • Sanchita Mandal

摘要

Gum Odina, an arabinogalactan-rich polysaccharide from Odina wodier, shows a new era as a multifunctional biomaterial for smart pharmaceutical and biomedical applications. This review is a critical summarization of the quantitative and qualitative information available on the source, purification, physicochemical properties, modification strategies, dosage form performance, and tissue regeneration potential, which is one of the major problems in biomedical engineering, particularly in wounds, bone defects, and periodontal repair. The modified gum Odina was addressed as an all-round biomaterial for the formation of scaffolds and hydrogels according to these requirements. The swelling index, release kinetics, cell viability, and wound contraction were tabulated, and drug release and adsorption profiles were interpreted via zero-order, Higuchi, Korsmeyer-Peppas, Langmuir, and Freundlich models. Studies have systematically reported porosity 75–95%, swelling indices the range of 250–300% (more in pH 6.5-7 and controlled in 1.2-2 pH), drug entrapment efficiencies often more than 70% and longer drug release periods (up to 24 h), removal efficiencies achieved for dyes > 90%, in vitro cell viability values in the order of 90%, and in vivo results in terms of wound contraction of 98% for 18 days, hydroxyproline of 240 ug/100 mg of tissue, enhanced collagen deposition, and accelerated re-epithelialization. Qualitative findings revealed the intrinsic biocompatibility, mucoadhesion, antioxidant and anti-inflammatory activity, prebiotic activity, and extracellular matrix-mimetic architecture of the scaffolds as crucial performance drivers. Altogether, the available evidence makes Odina gum a versatile, eco-friendly platform excipient and biomaterial for controlled drug delivery, therapeutic drugs directed towards the gut, wound healing, and tissue regeneration.

Graphical abstract