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<p>Bio-based polymeric scaffolds are being extensively investigated for sustainable therapeutic delivery systems due to their non-toxicity, biodegradability, and stimulus responses. This study reports the co-electrospinning of poly(lactic acid) (PLA), poly(caprolactone) (PCL), and nano-sized silk fibroin (SF) matrices to develop functional nanofibre mats, using a chloroform/DMF (1/1, v/v) mixture as the dope medium. The prepared tricomponent (SF/PLA/PCL) mats were loaded with gentamicin sulfate and evaluated for various chemical, physical, and structural properties. The results revealed that the electrospun mats had nanofibre diameters of 35 ± 2–72 ± 5&#xa0;μm, water contact angles of 41 ± 1-117 ± 2°, and tensile strengths of 10 ± 1–14 ± 1&#xa0;MPa, depending on the composition. The electrospun polymeric mats expressed pH-dependent first-order kinetics. The drug-loaded co-electrospun mat released 50.3 ± 3% of the drug at pH 7.4 after 24&#xa0;h in PBS. The study proposes that the gentamicin sulfate-loaded SF/PLA/PCL co-electrospun mat would be a promising template for pH-dependent sustained drug delivery.</p>

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Silk fibroin-mediated poly(lactic acid)/poly(caprolactone) co-electrospun mats for pH-sensitive drug delivery systems

  • 期刊论文

  • 发表日期：

    2026年1月27日

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  • Zulfiqar Ali Raza,
  • Rabia Shafi

摘要

Bio-based polymeric scaffolds are being extensively investigated for sustainable therapeutic delivery systems due to their non-toxicity, biodegradability, and stimulus responses. This study reports the co-electrospinning of poly(lactic acid) (PLA), poly(caprolactone) (PCL), and nano-sized silk fibroin (SF) matrices to develop functional nanofibre mats, using a chloroform/DMF (1/1, v/v) mixture as the dope medium. The prepared tricomponent (SF/PLA/PCL) mats were loaded with gentamicin sulfate and evaluated for various chemical, physical, and structural properties. The results revealed that the electrospun mats had nanofibre diameters of 35 ± 2–72 ± 5 μm, water contact angles of 41 ± 1-117 ± 2°, and tensile strengths of 10 ± 1–14 ± 1 MPa, depending on the composition. The electrospun polymeric mats expressed pH-dependent first-order kinetics. The drug-loaded co-electrospun mat released 50.3 ± 3% of the drug at pH 7.4 after 24 h in PBS. The study proposes that the gentamicin sulfate-loaded SF/PLA/PCL co-electrospun mat would be a promising template for pH-dependent sustained drug delivery.