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<p>The surface functionalization MFe<sub>2</sub>O<sub>4</sub> (M = Co, Ni, Zn) with Polyvinyl alcohol (PVA) by co-precipitation method, and serve as targeted drug delivery carriers in breast cancer therapy. The mean crystallite size of PVA@CF, PVA@NF, and PVA@ZF NCs was found to be 14.8 ± 0.3, 14.6 ± 0.3, and 9.7 ± 0.1&#xa0;nm, respectively from the XRD patterns. Spherical and random shape morphology of PVA@CF, PVA@NF, and PVA@ZF NPs was observed by HRTEM with the mean particle size of 13.9 ± 0.1, 9.5 ± 0.1, and 7.4 ± 0.1&#xa0;nm, respectively. RT dependent saturation magnetization 64.96, 38.94, and 20.07 (emu/g), remanence field 15.74, 0.55, and 0.02 (emu/g), and coercive field 474.45, 10.12, and 31.96 Oe were observed from M-H analysis of PVA@CF, PVA@NF, and PVA@ZF NCs, respectively. Sulforhodamine B (SRB) assay was employed to carry out anticancer activity of PVA@MF NCs against the MCF-7 cell line, and data reveals that cytotoxicity of PVA@NF was higher than PVA@CF, and PVA@NF NCs at concentrations range of 10–40&#xa0;µg/ml. At high dose (80&#xa0;µg/ml), % cell viability for PVA@NF (112.35%) and PVA@CF (101.09%) than the obtained for PVA@ZF (85.59%) respectively due to natural variations of cellular metabolism. The biocompatible PVA@MF NCs can be employed as a promising therapeutic agents in the applications of breast cancer therapy.</p>

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Impact of PVA coated MFe2O4 nanocomposites on the structural, morphological, spectroscopic, magnetic and anticancer properties

  • 期刊论文

  • 发表日期：

    2026年1月7日

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  • Kamlesh V. Chandekar,
  • Sharvari More,
  • Shamal Chinke,
  • Mohd Shkir,
  • Arjun R. Potinde,
  • Shashank S. Kamble,
  • Vibha Ojha

摘要

The surface functionalization MFe2O4 (M = Co, Ni, Zn) with Polyvinyl alcohol (PVA) by co-precipitation method, and serve as targeted drug delivery carriers in breast cancer therapy. The mean crystallite size of PVA@CF, PVA@NF, and PVA@ZF NCs was found to be 14.8 ± 0.3, 14.6 ± 0.3, and 9.7 ± 0.1 nm, respectively from the XRD patterns. Spherical and random shape morphology of PVA@CF, PVA@NF, and PVA@ZF NPs was observed by HRTEM with the mean particle size of 13.9 ± 0.1, 9.5 ± 0.1, and 7.4 ± 0.1 nm, respectively. RT dependent saturation magnetization 64.96, 38.94, and 20.07 (emu/g), remanence field 15.74, 0.55, and 0.02 (emu/g), and coercive field 474.45, 10.12, and 31.96 Oe were observed from M-H analysis of PVA@CF, PVA@NF, and PVA@ZF NCs, respectively. Sulforhodamine B (SRB) assay was employed to carry out anticancer activity of PVA@MF NCs against the MCF-7 cell line, and data reveals that cytotoxicity of PVA@NF was higher than PVA@CF, and PVA@NF NCs at concentrations range of 10–40 µg/ml. At high dose (80 µg/ml), % cell viability for PVA@NF (112.35%) and PVA@CF (101.09%) than the obtained for PVA@ZF (85.59%) respectively due to natural variations of cellular metabolism. The biocompatible PVA@MF NCs can be employed as a promising therapeutic agents in the applications of breast cancer therapy.