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<p>In this study, a stable macromolecular oil-in-water emulsion based on gelatin and pectin incorporating argan oil was first developed and characterized. This emulsion served as the basis for preparing composite films, to which a plasticizer was added to improve flexibility and swelling behavior, while the incorporation of oxidized pectin reduced the water-absorption capacity of the matrices. The films obtained showed a good pro-coagulant effect and marked antibacterial activity against <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i> (MIC = 20&#xa0;mg/mL). However, they had no antifungal activity, unlike the reference drug, which showed clear inhibition. With regard to wound healing, in vivo results on wounds in Wistar rats showed almost complete retraction (99%) after 8 days of treatment, which was significantly better than that obtained with the commercial dressing, whose retraction rate at the same stage was around 70%. In addition, the antioxidant activity demonstrated a remarkable synergy in formulations containing argan oil. Finally, a questionnaire distributed to healthcare professionals (doctors, pharmacists, dentists, chemists, etc.) enabled us to gain a better understanding of their perception of this type of oil-enriched biomaterial. Respondents expressed a strong interest, highlighting antimicrobial potential as the main perceived advantage, ahead of coagulation effects and anti-inflammatory properties. Statistical analyses (Chi-square tests) supported the interpretation of the survey responses, revealing profession-dependent differences in certain perceptions.</p>

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Stable macromolecular emulsion with argan oil for synergistic wound healing: from experimental evaluation to healthcare professionals’ perception

  • 期刊论文

  • 发表日期：

    2025年12月23日

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  • Asma Chetouani,
  • Hichem Haffar,
  • Meriem Elkolli,
  • Henni Chader

摘要

In this study, a stable macromolecular oil-in-water emulsion based on gelatin and pectin incorporating argan oil was first developed and characterized. This emulsion served as the basis for preparing composite films, to which a plasticizer was added to improve flexibility and swelling behavior, while the incorporation of oxidized pectin reduced the water-absorption capacity of the matrices. The films obtained showed a good pro-coagulant effect and marked antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa (MIC = 20 mg/mL). However, they had no antifungal activity, unlike the reference drug, which showed clear inhibition. With regard to wound healing, in vivo results on wounds in Wistar rats showed almost complete retraction (99%) after 8 days of treatment, which was significantly better than that obtained with the commercial dressing, whose retraction rate at the same stage was around 70%. In addition, the antioxidant activity demonstrated a remarkable synergy in formulations containing argan oil. Finally, a questionnaire distributed to healthcare professionals (doctors, pharmacists, dentists, chemists, etc.) enabled us to gain a better understanding of their perception of this type of oil-enriched biomaterial. Respondents expressed a strong interest, highlighting antimicrobial potential as the main perceived advantage, ahead of coagulation effects and anti-inflammatory properties. Statistical analyses (Chi-square tests) supported the interpretation of the survey responses, revealing profession-dependent differences in certain perceptions.