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<p>Over the past few decades, the incidence of chronic wound diseases has risen dramatically, significantly impairing the quality of life for diabetic patients. The development of advanced wound care products is essential to prevent amputations and reduce mortality rates. This study focuses on the electrospinning of polylactic acid (PLA), gelatin, glycine, and PAMAM (polyamidamine) dendrimer composites with <i>Melissa officinalis</i> extract, specifically for diabetic wound healing applications. Notably, we have for the first time incorporated PAMAM G4.0 with <i>Melissa officinalis</i> extract as an antibacterial and anti-inflammatory agent, investigating the impact of piezoelectric properties on the release behavior of the active ingredient. Our findings reveal a direct correlation between the piezoelectric characteristics of the nanofibers and the drug release response of PAMAM, achieving a maximum drug release of 99.5% over 180 <i>h</i>. Crystallographic analysis confirmed the formation of the β-crystalline phase of PLA and glycine during electrospinning, followed by heat treatment. Piezoelectric characterization yielded maximum output current and voltage readings of 22.44 <i>nA</i> and 9.82 <i>mV</i>, respectively. The fabricated nanofibers exhibited promising wound dressing properties, including a fluid absorption rate of 512.3% and a water vapor transmission rate (WVTR) of 2067 <i>g·m⁻²·day⁻¹</i>. Importantly, the integration of <i>Melissa officinalis</i> enhanced antibacterial and anti-inflammatory properties, leading to improved diabetic wound closure, collagen deposition, and neovascularization. Finally, our membranes demonstrated excellent cell proliferation with no observed cytotoxicity.</p>

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Advanced wound care: innovative electrospun poly (Lactic Acid)/Gelatin/Glycine nanofibers incorporating poly(amidoamine) dendrimers and Melissa officinalis for diabetic applications

  • 期刊论文

  • 发表日期：

    2025年12月29日

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  • Ghazaleh Chizari Fard,
  • Abbas Rahmani Azad,
  • Mazeyar Parvinzadeh Gashti

摘要

Over the past few decades, the incidence of chronic wound diseases has risen dramatically, significantly impairing the quality of life for diabetic patients. The development of advanced wound care products is essential to prevent amputations and reduce mortality rates. This study focuses on the electrospinning of polylactic acid (PLA), gelatin, glycine, and PAMAM (polyamidamine) dendrimer composites with Melissa officinalis extract, specifically for diabetic wound healing applications. Notably, we have for the first time incorporated PAMAM G4.0 with Melissa officinalis extract as an antibacterial and anti-inflammatory agent, investigating the impact of piezoelectric properties on the release behavior of the active ingredient. Our findings reveal a direct correlation between the piezoelectric characteristics of the nanofibers and the drug release response of PAMAM, achieving a maximum drug release of 99.5% over 180 h. Crystallographic analysis confirmed the formation of the β-crystalline phase of PLA and glycine during electrospinning, followed by heat treatment. Piezoelectric characterization yielded maximum output current and voltage readings of 22.44 nA and 9.82 mV, respectively. The fabricated nanofibers exhibited promising wound dressing properties, including a fluid absorption rate of 512.3% and a water vapor transmission rate (WVTR) of 2067 g·m⁻²·day⁻¹. Importantly, the integration of Melissa officinalis enhanced antibacterial and anti-inflammatory properties, leading to improved diabetic wound closure, collagen deposition, and neovascularization. Finally, our membranes demonstrated excellent cell proliferation with no observed cytotoxicity.