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<p>The aim of this study was to produce, characterize and evaluate the in vitro cytotoxicity of chitosan-based dressings enriched with turmeric in fibroblast cells (L929), as well as the antimicrobial potential using cultures of <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>. Three chitosan-based dressings were prepared: chitosan 1% (m/v; Chi); chitosan with 30% glycerol (ChiGly); and chitosan with 30% glycerol plus 1.5% turmeric (ChiGlyTur. All dressings were self-supporting and homogeneous, with ChiGly and ChiGlyTur exhibiting greater hydrophilicity compared to Chi. Vibrational bands characteristic of chitosan and glycerol were identified in all formulations. In cytotoxicity assays, all dressings showed increased metabolic activity and fibroblast proliferation at 72&#xa0;h compared to 24&#xa0;h. Antimicrobial tests demonstrated inhibition zones against both microorganisms, with ChiGlyTur showing the strongest effect. These findings provide preliminary evidence of the reparative and antimicrobial potential of medium molecular weight chitosan-based dressings, particularly those enriched with turmeric.</p>

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Biocompatibility and antimicrobial effects of chitosan/turmeric-based casting dressings

  • 期刊论文

  • 发表日期：

    2025年12月10日

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  • Daniela Bezerra Macedo,
  • Adriana Pavinatto,
  • Cintia Cristina Santi Martignago,
  • Juliana Bezerra Macedo,
  • Carla Roberta Tim,
  • Jynani Pichara Morais,
  • Valeska Bezerra Santana,
  • Ana Claudia Muniz Renno,
  • Lívia Assis

摘要

The aim of this study was to produce, characterize and evaluate the in vitro cytotoxicity of chitosan-based dressings enriched with turmeric in fibroblast cells (L929), as well as the antimicrobial potential using cultures of Staphylococcus aureus and Escherichia coli. Three chitosan-based dressings were prepared: chitosan 1% (m/v; Chi); chitosan with 30% glycerol (ChiGly); and chitosan with 30% glycerol plus 1.5% turmeric (ChiGlyTur. All dressings were self-supporting and homogeneous, with ChiGly and ChiGlyTur exhibiting greater hydrophilicity compared to Chi. Vibrational bands characteristic of chitosan and glycerol were identified in all formulations. In cytotoxicity assays, all dressings showed increased metabolic activity and fibroblast proliferation at 72 h compared to 24 h. Antimicrobial tests demonstrated inhibition zones against both microorganisms, with ChiGlyTur showing the strongest effect. These findings provide preliminary evidence of the reparative and antimicrobial potential of medium molecular weight chitosan-based dressings, particularly those enriched with turmeric.