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<p>Luteolin possesses anti-inflammatory, anti-allergic, and immune enhancing, while bacterial cellulose membrane (BCM) serves as an ideal drug carrier. To achieve efficient loading and sustained release of luteolin, this study developed a pH-responsive bacterial cellulose membrane modified with waterborne polyurethane (WPU) / 3-carboxyphenylboronic acid (PBA) / silica (SiO<sub>2</sub>). Using a single-factor optimization method, the effects of WPU dosage, PBA dosage, treatment time, treatment temperature, luteolin concentration, and pH value on the luteolin loading capacity of the composite modified membrane (CMBCM) were investigated, and its drug release behavior under different pH conditions was analyzed. The results showed that the optimal loading conditions were as follows: BCM modified with 10% WPU and 0.14&#xa0;g PBA, treated at 60℃ for 60&#xa0;min, followed by reaction with a 0.96&#xa0;g/L luteolin solution at 60℃ for 90&#xa0;min. Under these conditions, the K/S value of the membrane reached its maximum the loading effect is optimal. Furthermore, the composite membrane exhibited excellent stability at pH 4.56, and the release amount of luteolin increased with increasing pH. These findings demonstrate that the WPU/PBA/SiO<sub>2</sub>-modified bacterial cellulose membrane possesses pH-responsive drug release characteristics, indicating its potential application value in drug delivery for medical dressings.&#xa0;</p> Graphical Abstract <p></p>

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Luteolin loading and sustained-release on bacterial cellulose membranes with WPU/PBA/SiO2 by pH-response

  • 期刊论文

  • 发表日期：

    2025年12月12日

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  • Zhongliang Tian,
  • Zhi Wang,
  • Yutong Yao,
  • Xiang Liu,
  • Yong Wang,
  • Limin Zhang,
  • Xuemei He,
  • Jiqiang Cao

摘要

Luteolin possesses anti-inflammatory, anti-allergic, and immune enhancing, while bacterial cellulose membrane (BCM) serves as an ideal drug carrier. To achieve efficient loading and sustained release of luteolin, this study developed a pH-responsive bacterial cellulose membrane modified with waterborne polyurethane (WPU) / 3-carboxyphenylboronic acid (PBA) / silica (SiO2). Using a single-factor optimization method, the effects of WPU dosage, PBA dosage, treatment time, treatment temperature, luteolin concentration, and pH value on the luteolin loading capacity of the composite modified membrane (CMBCM) were investigated, and its drug release behavior under different pH conditions was analyzed. The results showed that the optimal loading conditions were as follows: BCM modified with 10% WPU and 0.14 g PBA, treated at 60℃ for 60 min, followed by reaction with a 0.96 g/L luteolin solution at 60℃ for 90 min. Under these conditions, the K/S value of the membrane reached its maximum the loading effect is optimal. Furthermore, the composite membrane exhibited excellent stability at pH 4.56, and the release amount of luteolin increased with increasing pH. These findings demonstrate that the WPU/PBA/SiO2-modified bacterial cellulose membrane possesses pH-responsive drug release characteristics, indicating its potential application value in drug delivery for medical dressings. 

Graphical Abstract