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<p>Infection and delayed wound healing are major concerns in the era of wound care. Recently, antibacterial wound dressings capable of improving wound healing have emerged as promising candidates in this field. In the present study, we have fabricated and characterized nanofibrous sheets composed of chitosan (CS), gum tragacanth (GT), gelatin (Gel), and poly(vinyl alcohol) (PVA), loaded with curcumin (Cur) nanoparticles. The mean diameter of the nanofibers was reduced from 218 ± 0.04&#xa0;nm to 152 ± 0.03&#xa0;nm after the addition of Cur. The FTIR spectra of prepared nanofibers indicated the presence of characteristic bands of each polymer, confirming the composite nature of the sheets. Moreover, the addition of Cur to the scaffolds decreased the degradation rate from 73.53 ± 22.49% to 64.38 ± 24.61%. Cur at a concentration of 0.5% was chosen as the cytocompatible concentration based on cell viability results. Additionally, no hemolysis of more than 2% was observed in any of the sheets, indicating their blood compatibility. The antibacterial activity was also observed in Cur-loaded scaffolds, whereas no antibacterial activity was seen in the sheets without Cur. The results achieved by this study demonstrate that PVA/CS/GT/Gel sheets containing 0.5% Cur can provide a promising solution for wound healing applications.</p>

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Nano-curcumin-loaded chitosan and gum tragacanth nanofibers for improved infectious wound healing

  • 期刊论文

  • 发表日期：

    2025年9月2日

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  • Khatereh Sadeqzadeh,
  • Seyedeh Najibeh Nasiri,
  • Fariba Alizadeh Eghtedar,
  • Zoleikha Azari,
  • Marziyeh Ranjbar-Mohammadi,
  • Zahra Nasrpour Navaei,
  • Roya Akbarpour,
  • Simin Nazarnezhad

摘要

Infection and delayed wound healing are major concerns in the era of wound care. Recently, antibacterial wound dressings capable of improving wound healing have emerged as promising candidates in this field. In the present study, we have fabricated and characterized nanofibrous sheets composed of chitosan (CS), gum tragacanth (GT), gelatin (Gel), and poly(vinyl alcohol) (PVA), loaded with curcumin (Cur) nanoparticles. The mean diameter of the nanofibers was reduced from 218 ± 0.04 nm to 152 ± 0.03 nm after the addition of Cur. The FTIR spectra of prepared nanofibers indicated the presence of characteristic bands of each polymer, confirming the composite nature of the sheets. Moreover, the addition of Cur to the scaffolds decreased the degradation rate from 73.53 ± 22.49% to 64.38 ± 24.61%. Cur at a concentration of 0.5% was chosen as the cytocompatible concentration based on cell viability results. Additionally, no hemolysis of more than 2% was observed in any of the sheets, indicating their blood compatibility. The antibacterial activity was also observed in Cur-loaded scaffolds, whereas no antibacterial activity was seen in the sheets without Cur. The results achieved by this study demonstrate that PVA/CS/GT/Gel sheets containing 0.5% Cur can provide a promising solution for wound healing applications.