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<p>Ag nanoparticles (AgNPs) were successfully embedded into a tragacanth gum-based composite hydrogel, synthesized via free radical polymerization using acrylamide and 2-acrylamido-2-methylpropanesulfonic acid (AMPS). The resulting hydrogel exhibited enhanced thermal stability, as confirmed by thermogravimetric analysis, and a semi-crystalline structure observed in X-ray Diffraction analysis. Scanning electron microscope images revealed a uniform dispersion of AgNPs within the hydrogel matrix. Swelling studies revealed a maximum swelling ratio of 650% at pH 9.0 for the AgNPs-anchored hydrogel, significantly higher than the AgNP-free hydrogel. Elemental analysis indicated an Ag content of 7.2% by weight. Antibacterial assays demonstrated strong activity against both <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, with minimum inhibitory concentration values of 2500&#xa0;µg/mL and 19.53&#xa0;µg/mL, respectively. These results highlight the potential of the developed mTG-g-p(Am-co-AMPS)-Ag nanocomposite hydrogel as an effective antibacterial material for biomedical and environmental applications.</p>

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Antibacterial activity of Ag nanoparticles embedded tragacanth gum-based composite hydrogel synthesized with acrylamide and 2-acrylamido-2-methylpropanesulfonic acid

  • 期刊论文

  • 发表日期：

    2025年7月9日

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  • Anuradha C. Hugar,
  • Manjunath S.Hanagadakar,
  • Jagadish N. Hiremath,
  • Anjanapura V. Raghu

摘要

Ag nanoparticles (AgNPs) were successfully embedded into a tragacanth gum-based composite hydrogel, synthesized via free radical polymerization using acrylamide and 2-acrylamido-2-methylpropanesulfonic acid (AMPS). The resulting hydrogel exhibited enhanced thermal stability, as confirmed by thermogravimetric analysis, and a semi-crystalline structure observed in X-ray Diffraction analysis. Scanning electron microscope images revealed a uniform dispersion of AgNPs within the hydrogel matrix. Swelling studies revealed a maximum swelling ratio of 650% at pH 9.0 for the AgNPs-anchored hydrogel, significantly higher than the AgNP-free hydrogel. Elemental analysis indicated an Ag content of 7.2% by weight. Antibacterial assays demonstrated strong activity against both Escherichia coli and Staphylococcus aureus, with minimum inhibitory concentration values of 2500 µg/mL and 19.53 µg/mL, respectively. These results highlight the potential of the developed mTG-g-p(Am-co-AMPS)-Ag nanocomposite hydrogel as an effective antibacterial material for biomedical and environmental applications.