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<p>A starch-based hydrogel was synthesised by direct grafting of polylactic acid and acrylamide onto starch. Potassium persulphate (K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>) was used as an initiator, and citric acid was used as an eco-friendly cross-linker. The purpose of the graft was to test an alternative anti-microbial wound dressing material. The FTIR, XRD, SEM and EDX data confirmed that the copolymerisation and cross-linking of the hydrogel were successful. Tests, with chemical reactions, yielded TGA data, which confirmed the enhanced thermal and mechanical properties of the augmented hydrogel. The hydrogel swelled up to 481% at pH 7.20 and exhibited a water vapour transmission rate of 148&#xa0;g/m<sup>2</sup> per day. The hydrogel also showed anti-microbial activity against both gram-positive (<i>S. aureus)</i> and gram-negative (<i>E. coli)</i> bacteria. Its zone of inhibition was 21&#xa0;mm and 19&#xa0;mm with a mild anti-oxidant property. This synthesised hydrogel is completely non-toxic and biodegradable, making it especially suitable as a wound dressing material.</p> Graphical abstract <p></p>

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Synthesis and characterisation of starch-g-polyacrylamide-co-polylactic acid hydrogel for the potential wound dressing application

  • 期刊论文

  • 发表日期：

    2025年6月11日

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  • H. Jahan Kadri,
  • Firoz Ahmed,
  • Md. Hasinur Rahman,
  • Md. Ibrahim H. Mondal

摘要

A starch-based hydrogel was synthesised by direct grafting of polylactic acid and acrylamide onto starch. Potassium persulphate (K2S2O8) was used as an initiator, and citric acid was used as an eco-friendly cross-linker. The purpose of the graft was to test an alternative anti-microbial wound dressing material. The FTIR, XRD, SEM and EDX data confirmed that the copolymerisation and cross-linking of the hydrogel were successful. Tests, with chemical reactions, yielded TGA data, which confirmed the enhanced thermal and mechanical properties of the augmented hydrogel. The hydrogel swelled up to 481% at pH 7.20 and exhibited a water vapour transmission rate of 148 g/m2 per day. The hydrogel also showed anti-microbial activity against both gram-positive (S. aureus) and gram-negative (E. coli) bacteria. Its zone of inhibition was 21 mm and 19 mm with a mild anti-oxidant property. This synthesised hydrogel is completely non-toxic and biodegradable, making it especially suitable as a wound dressing material.

Graphical abstract