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<p>L-asparaginase is a potent chemotherapy medication that effectively targets various forms of cancer, such as acute lymphoblastic leukemia. Nevertheless, its administration can be hampered by the emergence of hepatotoxicity. Therefore, implementing hepatoprotective measures is vital in alleviating L-asparaginase-induced hepatotoxicity and ensuring better health outcomes for patients. This study aims to investigate the potential hepatoprotective effects of nanoniosome-encapsulated phenolic-rich fraction of <i>Tanacetum</i> <i>parthenium</i> (NPEF-TP) in a mouse model of L-asparaginase-induced hepatotoxicity. The synthesized NPEF-TP exhibited a spherical structure with a size of 270&#xa0;nm and a polydispersity index coefficient of 0.25. The in vivo analysis showed that mice's weight and feed intake with hepatotoxicity significantly (<i>p</i> ≤ 0.05) enhanced after being treated with NPEF-TP. Additionally, the blood levels including triglyceride, cholesterol, liver enzymes (aspartate aminotransferase, alanine transaminase, and alkaline phosphatase), and total bilirubin were significantly (<i>p</i> ≤ 0.05) decreased. NPEF-TP treatment also led to a significant increase (<i>p</i> ≤ 0.05) in the blood levels of the antioxidant defense system (glutathione peroxidase, superoxide dismutase (SOD), and catalase). Moreover, NPEF-TP significantly down-regulated (<i>p</i> ≤ 0.05) the inducible nitric oxide synthase and interferon-gamma in the liver and up-regulated the expression of SOD as an antioxidant status biomarker gene. In conclusion, the findings of this study indicate that NPEF-TP may possess hepatoprotective properties through its antioxidant and anti-inflammatory activities. These results highlight the potential of NPEF-TP as a therapeutic intervention for mitigating L-asparaginase-induced hepatotoxicity and promoting liver health. Further investigations are warranted to elucidate the underlying mechanisms and to explore the translational potential of NPEF-TP in clinical settings.</p>

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Nanoniosomal formulation of Tanacetum parthenium phenolic compounds: a novel approach for hepatoprotection in L-asparaginase-induced hepatotoxicity

  • 期刊论文

  • 发表日期：

    2025年4月21日

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  • Laya golchin,
  • Sophia Bakhtparvar,
  • Anashid Bakhtparvar,
  • Ehsan Karimi,
  • Ehsan Oskoueian

摘要

L-asparaginase is a potent chemotherapy medication that effectively targets various forms of cancer, such as acute lymphoblastic leukemia. Nevertheless, its administration can be hampered by the emergence of hepatotoxicity. Therefore, implementing hepatoprotective measures is vital in alleviating L-asparaginase-induced hepatotoxicity and ensuring better health outcomes for patients. This study aims to investigate the potential hepatoprotective effects of nanoniosome-encapsulated phenolic-rich fraction of Tanacetum parthenium (NPEF-TP) in a mouse model of L-asparaginase-induced hepatotoxicity. The synthesized NPEF-TP exhibited a spherical structure with a size of 270 nm and a polydispersity index coefficient of 0.25. The in vivo analysis showed that mice's weight and feed intake with hepatotoxicity significantly (p ≤ 0.05) enhanced after being treated with NPEF-TP. Additionally, the blood levels including triglyceride, cholesterol, liver enzymes (aspartate aminotransferase, alanine transaminase, and alkaline phosphatase), and total bilirubin were significantly (p ≤ 0.05) decreased. NPEF-TP treatment also led to a significant increase (p ≤ 0.05) in the blood levels of the antioxidant defense system (glutathione peroxidase, superoxide dismutase (SOD), and catalase). Moreover, NPEF-TP significantly down-regulated (p ≤ 0.05) the inducible nitric oxide synthase and interferon-gamma in the liver and up-regulated the expression of SOD as an antioxidant status biomarker gene. In conclusion, the findings of this study indicate that NPEF-TP may possess hepatoprotective properties through its antioxidant and anti-inflammatory activities. These results highlight the potential of NPEF-TP as a therapeutic intervention for mitigating L-asparaginase-induced hepatotoxicity and promoting liver health. Further investigations are warranted to elucidate the underlying mechanisms and to explore the translational potential of NPEF-TP in clinical settings.