<p>Diabetic wounds are particularly challenging in healthcare due to their slow healing times and higher risk of bacterial infections, which can lead to serious complications like amputation. Chitosan, a natural polysaccharide derived from chitin, has gained considerable attention for its potential in developing advanced drug delivery systems specifically for diabetic wound care. Because chitosan is biocompatible and naturally degradable by the body, it’s effective in supporting wound healing, making it a promising option for creating drug delivery systems that allow for controlled drug release, promote tissue regeneration, and help prevent infections. Chitosan’s ability to stick to membranes ensures that drugs stay at the wound site, increasing their effectiveness. Additionally, its clotting and antimicrobial properties make it ideal for use in wound dressings and scaffolds. Recent studies have shown that chitosan-based formulations, including nanoparticles, hydrogels, microneedles, and nanofiber dressings, can speed up wound closure, reduce inflammation, and improve overall healing. These innovative chitosan-based approaches are opening new avenues in wound care, offering better outcomes for patients.</p> Graphical abstract <p></p>