<p>In sectors such as pharmaceuticals, microelectronics, biotechnology, and healthcare, clean room filters are essential to upholding strict air quality standards. In order to provide a regulated atmosphere necessary for high-precision manufacturing and research, these filters are made to capture airborne pollutants such as particles, bacteria, and chemical vapors. The functionality of clean room filters is examined in this paper, with particular attention paid to new developments, material composition, filtration processes, and efficiency. Ultra-low penetration air (ULPA) and high-efficiency particulate air (HEPA) filters continue to be the industry standard, using electret-based improvements and fibrous media to achieve greater performance. Important functional characteristics are looked at, including durability, airflow resistance, particle collection efficiency, and resistance to microbiological contamination. It also emphasizes the use of sustainable substitutes, such as biodegradable and energy-efficient filtration media, as well as nanofiber-based filters. There is also discussion of new developments in smart filtration technology that use sensors and real-time monitoring systems. The assessment emphasizes how clean room filtration requires constant innovation to improve performance and solve environmental issues. Next-generation clean room filters can achieve greater efficiency, longer operational lifespans, and less environmental impact by combining innovative materials and automated monitoring. This study helps to shape future research and industry applications by offering insights into the changing field of clean room filtration.</p>