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<p>Nisin is a potential antimicrobial peptide that is used in various applications such as food safety, healthcare, and agriculture. Recent research suggests that the traditional delivery system faces limitations such as low bioavailability, susceptibility to proteolytic degradation, and potential toxicity, which hinder its application in therapeutic and industrial fields. This study explores advanced nano drug delivery systems that enhance nisin stability, efficacy, and targeted delivery through key approaches such as encapsulation in nanoparticles, nanofibers, liposomes, hydrogels, and cyclodextrins—each offering unique advantages for improving nisin bioavailability and controlled release. Nanoparticles and nano emulsions enhance nisin antimicrobial properties and solubility, while nanofibers and hydrogels offer sustained release, particularly beneficial for wound healing. Quantitative analyses reveal that nanoparticle-based delivery improves the stability of nisin up to 75% retention with increased stability compared to 54% with conventional methods. Also, the antimicrobial inhibition has been increased up to 68% compared to 50% for free nisin. Nanofiber and hydrogel systems exhibit a sustained release efficiency of 80%, compared to 53% as observed with standard formulations. Cyclodextrins further improve nisin stability and potency, especially in food preservation and cancer therapy. This review highlights the potential of these delivery systems to mitigate nisin limitations and suggests future directions focusing on sustainability, controlled drug release, and innovative strategies for broader applications across medical, food, and agricultural industries.</p>

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Nano delivery platforms for nisin, a potent cyclic peptide: a comprehensive review of biological applications

  • 期刊论文

  • 发表日期：

    2025年3月17日

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  • Alan Joy,
  • Nithesh Jerome,
  • Shruthi Uthanda Ramakrishnan,
  • Sangeetha Jeyaraman,
  • Dharshini Vijayakumar,
  • Canivizhi Vidjeyamannane,
  • Kishore Prakash,
  • Rashmi Priyadarshi Sharma,
  • Aravind Ganessin,
  • Rupachandra Saravanakumar

摘要

Nisin is a potential antimicrobial peptide that is used in various applications such as food safety, healthcare, and agriculture. Recent research suggests that the traditional delivery system faces limitations such as low bioavailability, susceptibility to proteolytic degradation, and potential toxicity, which hinder its application in therapeutic and industrial fields. This study explores advanced nano drug delivery systems that enhance nisin stability, efficacy, and targeted delivery through key approaches such as encapsulation in nanoparticles, nanofibers, liposomes, hydrogels, and cyclodextrins—each offering unique advantages for improving nisin bioavailability and controlled release. Nanoparticles and nano emulsions enhance nisin antimicrobial properties and solubility, while nanofibers and hydrogels offer sustained release, particularly beneficial for wound healing. Quantitative analyses reveal that nanoparticle-based delivery improves the stability of nisin up to 75% retention with increased stability compared to 54% with conventional methods. Also, the antimicrobial inhibition has been increased up to 68% compared to 50% for free nisin. Nanofiber and hydrogel systems exhibit a sustained release efficiency of 80%, compared to 53% as observed with standard formulations. Cyclodextrins further improve nisin stability and potency, especially in food preservation and cancer therapy. This review highlights the potential of these delivery systems to mitigate nisin limitations and suggests future directions focusing on sustainability, controlled drug release, and innovative strategies for broader applications across medical, food, and agricultural industries.