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<p>In this work, we present a fundamental mathematical model for proton transport, tailored to capture the key physical processes underpinning Proton Beam Therapy (PBT). The model provides a robust and computationally efficient framework for exploring various aspects of PBT, including dose delivery, linear energy transfer, treatment planning and the evaluation of relative biological effectiveness. Our findings highlight the potential of this model as a complementary tool to more complex and computationally intensive simulation techniques currently used in clinical practice.</p>

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Efficient proton transport modelling for proton beam therapy and biological quantification

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月11日

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  • Ben S. Ashby,
  • Veronika Chronholm,
  • Daniel K. Hajnal,
  • Alex Lukyanov,
  • Katherine MacKenzie,
  • Aaron Pim,
  • Tristan Pryer

摘要

In this work, we present a fundamental mathematical model for proton transport, tailored to capture the key physical processes underpinning Proton Beam Therapy (PBT). The model provides a robust and computationally efficient framework for exploring various aspects of PBT, including dose delivery, linear energy transfer, treatment planning and the evaluation of relative biological effectiveness. Our findings highlight the potential of this model as a complementary tool to more complex and computationally intensive simulation techniques currently used in clinical practice.