Scholarlink

<p>Koi (<i>Cyprinus rubrofuscus</i>) is a world-famous ornamental fish known for its unique characteristics and economic value. This species is susceptible to various infections, leading to high mortality and morbidity rates. In this study, bacterial pathogens isolated from naturally diseased koi were identified as belonging mainly to the genera <i>Aeromonas</i> and <i>Proteus</i> through comprehensive characterisation and molecular identification. Experimental infections with <i>Proteus</i> sp. closely related to <i>Proteus vulgaris</i> (<i>vulgaris</i>/<i>hauseri</i> complex) showed some clinical signs very similar to those in naturally infected koi, suggesting that <i>Proteus</i> sp. in this study is a possible pathogen in addition to <i>Aeromonas</i>, indicating a potential co-infection. The median lethal dose (LD50) for <i>Proteus</i> sp. was determined to be 1.7 × 10<sup>8</sup> CFU/mL, with histopathological analysis showing changes such as fusions, lymphocyte aggregation, and necrosis in the kidney and liver. The bacterium was found to be sensitive to various antibiotics, suggesting that broad-spectrum antibiotics may be effective in treating the pathogen. This study represents the isolation of <i>Proteus</i> sp. closely related to <i>P. vulgaris</i> (<i>vulgaris</i>/<i>hauseri</i> complex) from koi and provides valuable insights for the prevention and management of related disease outbreaks. The study on bacterial infections in koi fish, particularly the isolation and characterization of <i>Aeromonas</i> species alongside <i>Proteus</i> sp., highlights significant implications for koi health management. The findings underscore the pathogenicity, potential for coinfection, and the susceptibility of <i>Proteus</i> sp. to broad-spectrum antibiotics, providing key understanding for disease outbreak management in ornamental koi populations.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Isolation of Proteus sp. Closely Related to P. Vulgaris (Vulgaris/hauseri Complex) from Ornamental Koi (Cyprinus rubrofuscus) and its Pathogenicity

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月12日

查看全文
  • Crystal Jia Jing Lim,
  • Hung Hui Chung,
  • Melinda Mei Lin Lau,
  • Cindy Jia Yung Kho,
  • Leonard Whye Kit Lim,
  • Kristene Ling Yong,
  • Pei Xuan Hew

摘要

Koi (Cyprinus rubrofuscus) is a world-famous ornamental fish known for its unique characteristics and economic value. This species is susceptible to various infections, leading to high mortality and morbidity rates. In this study, bacterial pathogens isolated from naturally diseased koi were identified as belonging mainly to the genera Aeromonas and Proteus through comprehensive characterisation and molecular identification. Experimental infections with Proteus sp. closely related to Proteus vulgaris (vulgaris/hauseri complex) showed some clinical signs very similar to those in naturally infected koi, suggesting that Proteus sp. in this study is a possible pathogen in addition to Aeromonas, indicating a potential co-infection. The median lethal dose (LD50) for Proteus sp. was determined to be 1.7 × 108 CFU/mL, with histopathological analysis showing changes such as fusions, lymphocyte aggregation, and necrosis in the kidney and liver. The bacterium was found to be sensitive to various antibiotics, suggesting that broad-spectrum antibiotics may be effective in treating the pathogen. This study represents the isolation of Proteus sp. closely related to P. vulgaris (vulgaris/hauseri complex) from koi and provides valuable insights for the prevention and management of related disease outbreaks. The study on bacterial infections in koi fish, particularly the isolation and characterization of Aeromonas species alongside Proteus sp., highlights significant implications for koi health management. The findings underscore the pathogenicity, potential for coinfection, and the susceptibility of Proteus sp. to broad-spectrum antibiotics, providing key understanding for disease outbreak management in ornamental koi populations.