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<p>This study investigated the presence and genetic diversity of porcine circovirus type 3 (PCV3) in Vietnam. Fifteen samples from sows with reproductive disorders across five provinces were screened by qPCR; those with Ct-values &lt; 25 underwent sequencing. Whole-genome analysis revealed multiple polymorphisms, including a notable A24L substitution in the ORF2 Cap protein. Phylogenetic results showed 13 strains belonged to genotype PCV3b, while two were PCV3a (PCV3a-1 and PCV3a-IM), suggesting PCV3b predominance in Vietnam. Additionally, PCV3a-2 was significantly associated with respiratory and digestive disorders (<i>p</i> ≤ 0.001). These findings highlight PCV3’s clinical relevance and support genotype-based classification for future vaccine and control efforts.</p>

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Genetic Characterization and Evidence of Capsid Epitope Variation in Porcine Circovirus Type 3 Strains from Vietnamese Swine with Reproductive Disorders

  • 期刊论文

  • 发表日期：

    2025年11月8日

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  • Long Ngoc Huynh Pham ,
  • Phat Xuan Dinh,
  • Tram Ngoc Thi Ngo,
  • Ha Thu Thi Le,
  • Duy Tien Do

摘要

This study investigated the presence and genetic diversity of porcine circovirus type 3 (PCV3) in Vietnam. Fifteen samples from sows with reproductive disorders across five provinces were screened by qPCR; those with Ct-values < 25 underwent sequencing. Whole-genome analysis revealed multiple polymorphisms, including a notable A24L substitution in the ORF2 Cap protein. Phylogenetic results showed 13 strains belonged to genotype PCV3b, while two were PCV3a (PCV3a-1 and PCV3a-IM), suggesting PCV3b predominance in Vietnam. Additionally, PCV3a-2 was significantly associated with respiratory and digestive disorders (p ≤ 0.001). These findings highlight PCV3’s clinical relevance and support genotype-based classification for future vaccine and control efforts.