Scholarlink

<p>Antibiotic-resistant <i>Staphylococcus aureus</i> (<i>S. aureus</i>) has severely threatened public health, colonizing approximately 20% of the human population. Thus, targeting <i>S. aureus</i> virulence factors appears to be a promising strategy for infection control. In this study, DP treatment significantly reduced sortase activity, inhibiting <i>S. aureus</i> adhesion and invasion. Computational biology and site-directed mutagenesis confirmed that DP bound to sortase via P30 and T105 residues, which occupied the active center of sortase and inhibited its activity. Additionally, treatment with DP significantly reduced the mortality rate of <i>S. aureus</i>-infected mice and reduced pathological damage to their lungs. Our findings may provide a new agent for developing anti-virulence agents against <i>S. aureus</i>, specifically MRSA infection.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Dracorhodin Perchlorate Targets SrtA To Alleviate Staphylococcus Aureus Pneumonia Infection in Vitro and in Vivo

  • 期刊论文

  • 发表日期：

    2025年12月20日

查看全文
  • Chenyi Zhang,
  • Chunhua Li,
  • Haiyang Wang,
  • Cuiqing Zhao,
  • Yumin Liu

摘要

Antibiotic-resistant Staphylococcus aureus (S. aureus) has severely threatened public health, colonizing approximately 20% of the human population. Thus, targeting S. aureus virulence factors appears to be a promising strategy for infection control. In this study, DP treatment significantly reduced sortase activity, inhibiting S. aureus adhesion and invasion. Computational biology and site-directed mutagenesis confirmed that DP bound to sortase via P30 and T105 residues, which occupied the active center of sortase and inhibited its activity. Additionally, treatment with DP significantly reduced the mortality rate of S. aureus-infected mice and reduced pathological damage to their lungs. Our findings may provide a new agent for developing anti-virulence agents against S. aureus, specifically MRSA infection.