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<p>Biofilms represent intricate microbial consortia adhering to surfaces, posing substantial challenges in medical and industrial contexts due to their formidable resistance to antimicrobial agents and host immune responses. These communities exhibit enhanced resilience over planktonic cells, necessitating innovative control and eradication strategies. Inducing biofilm dispersion has emerged as a promising strategy, garnering significant research interest. This review synthesizes recent advancements in biofilm dispersion, delineating the characteristics of dispersed cells, elucidating the molecular and environmental triggers of dispersion, and examining the ramifications of dispersal events. Furthermore, it underscores the therapeutic potential of leveraging dispersion to manage biofilm-associated infections and mitigate biofilm formation. By dissecting the mechanisms and implications of biofilm dispersion, this review enriches our understanding of biofilm dynamics and offers novel avenues for addressing biofilm-related challenges across diverse environments. Ultimately, harnessing dispersal mechanisms presents a paradigm shift in biofilm control, offering a powerful strategy to overcome treatment failures in chronic infections and to enhance efficacy in industrial biofouling mitigation.</p>

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Dispersal Mechanisms in Biofilm Control: Characteristics, Induction, Impacts, and Therapeutic Potential

  • 期刊论文

  • 发表日期：

    2025年11月5日

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  • Javad Yasbolaghi Sharahi,
  • Amirhossein Fayyazi,
  • Mansoor Kodori,
  • Minoo Hosseinpour,
  • Ali Hashemi,
  • Mohammad Mahmoudi,
  • Fariba Rafiei

摘要

Biofilms represent intricate microbial consortia adhering to surfaces, posing substantial challenges in medical and industrial contexts due to their formidable resistance to antimicrobial agents and host immune responses. These communities exhibit enhanced resilience over planktonic cells, necessitating innovative control and eradication strategies. Inducing biofilm dispersion has emerged as a promising strategy, garnering significant research interest. This review synthesizes recent advancements in biofilm dispersion, delineating the characteristics of dispersed cells, elucidating the molecular and environmental triggers of dispersion, and examining the ramifications of dispersal events. Furthermore, it underscores the therapeutic potential of leveraging dispersion to manage biofilm-associated infections and mitigate biofilm formation. By dissecting the mechanisms and implications of biofilm dispersion, this review enriches our understanding of biofilm dynamics and offers novel avenues for addressing biofilm-related challenges across diverse environments. Ultimately, harnessing dispersal mechanisms presents a paradigm shift in biofilm control, offering a powerful strategy to overcome treatment failures in chronic infections and to enhance efficacy in industrial biofouling mitigation.