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<p>Lung cancer is the leading cause of cancer-related deaths worldwide. The gut microbiota is known to be involved in the occurrence and development of a variety of cancers, but the role of gut microbiota in lung cancer remains unclear. Here, we selected fecal samples of lung cancer patients and healthy people for <i>16S rRNA</i> high-throughput sequencing and untargeted metabolomics analysis, respectively. The results showed that <i>Actinobacteria</i>, <i>Proteobacteria</i>, <i>Patescibacteria</i>, <i>Cyanobacteria</i> and <i>Verrucomicrobiota</i> were enriched in the LC; And the interaction between bacteria in the LC was more complicated than that in the NC. ROC showed that <i>Actinobacteriota</i>, <i>Bacteroidota</i>, <i>Verrucomicrobiota</i> and 7 kinds of bacteria at the genus have a better resolution for LC There are 82 kinds of metabolites that were different between NC and LC, mainly lipid metabolism molecules KEGG analysis indicated that Glycerophospholipid metabolism and alpha-Linolenic acid metabolism may be different in the LC and NC. ROC showed that 15 kinds of metabolites had a better classification effect on LC and NC; And we found that the correlation between metabolites in NC was higher than that in LC. This article pointed out the direction for follow-up research on its role in the occurrence and development of lung cancer.</p>

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Alterations in the Gut Microbiota and Metabolite Profiles of Lung Cancer Patients

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • Nan Li,
  • Qiliu Qian,
  • Jun Ouyang,
  • Mingyue Hu,
  • Ligong Chang,
  • Shiya Zheng

摘要

Lung cancer is the leading cause of cancer-related deaths worldwide. The gut microbiota is known to be involved in the occurrence and development of a variety of cancers, but the role of gut microbiota in lung cancer remains unclear. Here, we selected fecal samples of lung cancer patients and healthy people for 16S rRNA high-throughput sequencing and untargeted metabolomics analysis, respectively. The results showed that Actinobacteria, Proteobacteria, Patescibacteria, Cyanobacteria and Verrucomicrobiota were enriched in the LC; And the interaction between bacteria in the LC was more complicated than that in the NC. ROC showed that Actinobacteriota, Bacteroidota, Verrucomicrobiota and 7 kinds of bacteria at the genus have a better resolution for LC There are 82 kinds of metabolites that were different between NC and LC, mainly lipid metabolism molecules KEGG analysis indicated that Glycerophospholipid metabolism and alpha-Linolenic acid metabolism may be different in the LC and NC. ROC showed that 15 kinds of metabolites had a better classification effect on LC and NC; And we found that the correlation between metabolites in NC was higher than that in LC. This article pointed out the direction for follow-up research on its role in the occurrence and development of lung cancer.