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<p>Biofilms play a crucial role in persistent infections and antibiotic resistance owing to their structural complexity and protective matrices. This review focuses on current antibiofilm techniques to avoid or inhibit microbial colonisation. Key approaches involve the employing of antimicrobial peptides, quorum sensing inhibitors, quorum quenching agents, matrix-degrading enzymes, nanoparticles, and bacteriophages. These techniques inhibit biofilm formation, increase antimicrobial penetration, and impede biofilm integrity. The focus is on <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>, two clinically relevant biofilm-forming bacteria. Quorum quenching, which interrupts microbial communication networks, has emerged as a viable technique for inhibiting pathogenesis and biofilm growth. Efforts have been made to identify various compounds used for inhibiting quorum Sensing. Various plant extracts and enzymes have been proven to affect quorum sensing profoundly. Another strategy is to inhibit the genes responsible for biofilm formation. Certain genes can be upregulated or downregulated to prevent biofilm formation, or component production can be minimised. A multidisciplinary strategy that incorporates these tactics can give effective approaches for treating biofilm-related illnesses in healthcare and industrial settings.</p>

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The Impact of Antibiofilm Strategies in Controlling Microbial Colonization

  • 期刊论文

  • 发表日期：

    2025年6月30日

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  • Binimol Jacob Karayamparambil,
  • Kayeen Vadakkan,
  • Sinjumol Thomas

摘要

Biofilms play a crucial role in persistent infections and antibiotic resistance owing to their structural complexity and protective matrices. This review focuses on current antibiofilm techniques to avoid or inhibit microbial colonisation. Key approaches involve the employing of antimicrobial peptides, quorum sensing inhibitors, quorum quenching agents, matrix-degrading enzymes, nanoparticles, and bacteriophages. These techniques inhibit biofilm formation, increase antimicrobial penetration, and impede biofilm integrity. The focus is on Pseudomonas aeruginosa and Staphylococcus aureus, two clinically relevant biofilm-forming bacteria. Quorum quenching, which interrupts microbial communication networks, has emerged as a viable technique for inhibiting pathogenesis and biofilm growth. Efforts have been made to identify various compounds used for inhibiting quorum Sensing. Various plant extracts and enzymes have been proven to affect quorum sensing profoundly. Another strategy is to inhibit the genes responsible for biofilm formation. Certain genes can be upregulated or downregulated to prevent biofilm formation, or component production can be minimised. A multidisciplinary strategy that incorporates these tactics can give effective approaches for treating biofilm-related illnesses in healthcare and industrial settings.