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<p>Pyocyanin, the nitrogen-containing heterocyclic phenazine compound produced by <i>Pseudomonas aeruginosa</i>, has been proven to be a potential drug of choice against vibriosis in sustainable aquaculture production systems. Considering the cost of production and the fact that pyocyanin is produced in very small quantities in nature genetic improvement of bacterial strains for enhanced production of pyocyanin is a requirement. In-depth studies on the key biomolecules behind the biosynthesis of pyocyanin in <i>P.aeruginosa</i> has been conducted previously, however, gene level manipulations of the pyocyanin biosynthetic pathway has to be experimented enhancing the yield in <i>P.aeruginosa</i>. In this review, we look in to the molecular mechanism behind pyocyanin production in <i>P. aeruginosa</i> and an attempt has been made to investigate the growing scope of microbial synthetic biology in pyocyanin biosynthesis. In the present scenario where, synthetic biology-based tools are gaining much importance, this review throws light to building up a platform for synthetic biology-based production of pyocyanin.</p>

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Prospects of Synthetic Biology-Based Approaches in the Enhanced Production of Pyocyanin in Pseudomonas aeruginosa MCCB 117 as the Drug of Choice in Aquaculture

  • 期刊论文

  • 发表日期：

    2025年6月3日

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  • Jini Jimmy,
  • Jayesh Puthumana,
  • Valsamma Joseph,
  • I. S. Bright Singh

摘要

Pyocyanin, the nitrogen-containing heterocyclic phenazine compound produced by Pseudomonas aeruginosa, has been proven to be a potential drug of choice against vibriosis in sustainable aquaculture production systems. Considering the cost of production and the fact that pyocyanin is produced in very small quantities in nature genetic improvement of bacterial strains for enhanced production of pyocyanin is a requirement. In-depth studies on the key biomolecules behind the biosynthesis of pyocyanin in P.aeruginosa has been conducted previously, however, gene level manipulations of the pyocyanin biosynthetic pathway has to be experimented enhancing the yield in P.aeruginosa. In this review, we look in to the molecular mechanism behind pyocyanin production in P. aeruginosa and an attempt has been made to investigate the growing scope of microbial synthetic biology in pyocyanin biosynthesis. In the present scenario where, synthetic biology-based tools are gaining much importance, this review throws light to building up a platform for synthetic biology-based production of pyocyanin.