<p>Body dysmorphic disorder (BDD) is characterized by a&#xa0;persistent preoccupation with perceived or minor physical flaws. Due to the reclassification under “obsessive-compulsive and related disorders” in ICD-11, mutual transdiagnostic constructs are empirically examined. The aim of the study was to examine whether individuals with body dysmorphic symptoms experience greater intolerance of uncertainty (UI), interoceptive dysfunction and increased self-disgust compared to individuals without body dysmorphic symptoms and to what extent these factors are associated with the severity of body dysmorphic symptoms. Especially UI but also uncertainty regarding interoceptive signals, could promote safety-seeking behavior. For this, <i>N</i> = 102 women were surveyed using self-report instruments for intolerance of uncertainty (UI-18), facets of interoception (MAIA-2) and self-disgust (FESE). The diagnostic classification of BDD relied on the diagnostic interview body dysmorphic disorder diagnostic module (BDDDM) and symptom severity was assessed by the semi-structured clinical interview BDD Yale-Brown obsessive-compulsive scale (BDD-YBOCS). It was found that individuals with (sub)clinical BDD (<i>n</i> = 53) differed significantly from controls without BDD symptoms (<i>n</i> = 49) in terms of the extent of intolerance of uncertainty, self-disgust and some facets of interoception (all <i>p</i> &lt; 0.05). The BDD symptom severity (BDD-YBOCS) correlated with UI (<i>r</i> = 0.28), self-disgust (<i>r</i> = 0.44) and facets of interoception (<i>r</i> = −0.25 to −0.52). Despite the cross-sectional design, the results emphasize the need to further investigate the constructs as factors that can promote and maintain BDD.</p>