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<p>Among prognostic factors influencing the achievement of molecular responses in chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors (TKIs), age has been suggested with contrasting results, while the role of gender is still uncertain. A large cohort of 1,394 newly diagnosed CML patients was analyzed by data collected in the Italian CML Network, evaluating the effect of age and gender on the probability of deep molecular responses (DMR). With a median follow-up of 5 years, female patients showed a higher rate of DMR as compared to males. The effect, constant over time, was more evident with imatinib and dasatinib. Indeed, age did not influence the probability of DMR, when considered overall or stratified according to the type of TKI. In a real-world analysis, it seems that age has no effect on DMR regardless of the TKI class, while female gender can be confirmed as significant prognostic factor.</p>

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Age and gender effects on molecular responses in chronic myeloid leukemia patients by first-line treatment: an Italian CML network cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月18日

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  • Massimo Breccia,
  • Valentina Giai,
  • Tiziana Rosso,
  • Patrizia Pregno,
  • Fausto Castagnetti,
  • Massimiliano Bonifacio,
  • Isabella Capodanno,
  • Mario Tiribelli,
  • Fabio Stagno,
  • Giovanni Caocci,
  • Antonella Gozzini,
  • Andrea Patriarca,
  • Federica Sorà,
  • Giuseppina Loglisci,
  • Antonella Russo Rossi,
  • Maria Rosaria Coppi,
  • Maria Cristina Miggiano,
  • Francesco Di Raimondo,
  • Sara Galimberti,
  • Gianantonio Rosti,
  • Lorella Melillo,
  • Fabrizio Pane,
  • Giuseppe Saglio,
  • Giovannino Ciccone,
  • Giorgina Specchia

摘要

Among prognostic factors influencing the achievement of molecular responses in chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors (TKIs), age has been suggested with contrasting results, while the role of gender is still uncertain. A large cohort of 1,394 newly diagnosed CML patients was analyzed by data collected in the Italian CML Network, evaluating the effect of age and gender on the probability of deep molecular responses (DMR). With a median follow-up of 5 years, female patients showed a higher rate of DMR as compared to males. The effect, constant over time, was more evident with imatinib and dasatinib. Indeed, age did not influence the probability of DMR, when considered overall or stratified according to the type of TKI. In a real-world analysis, it seems that age has no effect on DMR regardless of the TKI class, while female gender can be confirmed as significant prognostic factor.