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<p>Extramedullary disease in patients with newly diagnosed multiple myeloma is rare and, despite the abundance of new therapeutic options, is still associated with a dismal prognosis, classifying as an unmet clinical need. Here, we report the case of a young woman diagnosed with multiple myeloma and extensive extramedullary disease characterised by diffuse lymph node involvement. The patient received multiple chemotherapy regimens proving to be refractory to all of them and ultimately benefited from salvage therapy with Venetoclax combination therapy, with a complete disappearance of the extramedullary manifestations. This case proves the effectiveness of Venetoclax in t(11;14) myeloma with extramedullary involvement.</p>

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Effectiveness of venetoclax based therapy in t(11;14) multiple myeloma with extensive extramedullary disease: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月27日

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  • Kerstin Brinkert,
  • Bernd Heinrich,
  • Annamaria Brioli,
  • Michael Heuser,
  • Hans Heinrich Kreipe,
  • Florian H. Heidel,
  • Arnold Ganser,
  • Gernot Beutel

摘要

Extramedullary disease in patients with newly diagnosed multiple myeloma is rare and, despite the abundance of new therapeutic options, is still associated with a dismal prognosis, classifying as an unmet clinical need. Here, we report the case of a young woman diagnosed with multiple myeloma and extensive extramedullary disease characterised by diffuse lymph node involvement. The patient received multiple chemotherapy regimens proving to be refractory to all of them and ultimately benefited from salvage therapy with Venetoclax combination therapy, with a complete disappearance of the extramedullary manifestations. This case proves the effectiveness of Venetoclax in t(11;14) myeloma with extramedullary involvement.