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<p>In most cases of anaplastic lymphoma kinase–positive anaplastic large cell lymphoma (ALK + ALCL), long-term survival is achieved using CHOP therapy. However, some cases have a poor prognosis. Here, we investigated the clinical impact of <i>TP53</i> deletion on adult ALK + ALCL patients via a multicenter, retrospective analysis. <i>TP53</i> deletion was evaluated by fluorescence in situ hybridization (FISH) using paraffin sections of lymphoma samples. To re-evaluate the FISH results, whole genome copy number changes were analyzed in DNA extracted from paraffin sections using OncoScan analysis. Fourteen patients treated with first-line chemotherapy enrolled at six centers were analyzed. All patients received CHOP-based therapy as initial therapy. The 5-year progression-free survival (PFS) and overall survival (OS) of the 14 patients were 28.6% (median 7&#xa0;months) and 57.1% (median 99&#xa0;months), respectively. FISH analysis revealed 6 (43%) patients were positive for <i>TP53</i> deletion (deletion group) and 8 (57%) were negative (non-deletion group). All six patients in the deletion group were diagnosed at an advanced stage; five were refractory to initial treatment, one relapsed after treatment, and all patients died of ALK + ALCL. The median PFS was 3.5&#xa0;months in the deletion group and 76&#xa0;months in the non-deletion group. The median OS was 7&#xa0;months in the deletion group and has yet to be confirmed in the non-deletion group. OncoScan analysis showed <i>TP53</i> copy number reduction in the deletion group and no <i>TP53</i> copy number abnormalities in the non-deletion group. This study suggests that <i>TP53</i> deletion is a poor prognostic factor in ALK + ALCL treated with CHOP-based therapy.</p>

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TP53 deletion is associated with poor survival of adult ALK-positive ALCL patients receiving CHOP-based chemotherapy

  • 期刊论文

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  • 发表日期：

    2025年3月10日

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  • Seiichiro Katagiri,
  • Daigo Akahane,
  • Kunihiko Takeyama,
  • Norihide Sato,
  • Nobuyuki Takayama,
  • Jun Ando,
  • Hideaki Nitta,
  • Masaaki Noguchi,
  • Ken Naganuma,
  • Shuji Momose,
  • Takayuki Tabayashi,
  • Masahiro Kizaki,
  • Hiroshi Kawada,
  • Yara Yukie Kikuti,
  • Joaquim Carreras,
  • Naoya Nakamura,
  • Akihiko Gotoh

摘要

In most cases of anaplastic lymphoma kinase–positive anaplastic large cell lymphoma (ALK + ALCL), long-term survival is achieved using CHOP therapy. However, some cases have a poor prognosis. Here, we investigated the clinical impact of TP53 deletion on adult ALK + ALCL patients via a multicenter, retrospective analysis. TP53 deletion was evaluated by fluorescence in situ hybridization (FISH) using paraffin sections of lymphoma samples. To re-evaluate the FISH results, whole genome copy number changes were analyzed in DNA extracted from paraffin sections using OncoScan analysis. Fourteen patients treated with first-line chemotherapy enrolled at six centers were analyzed. All patients received CHOP-based therapy as initial therapy. The 5-year progression-free survival (PFS) and overall survival (OS) of the 14 patients were 28.6% (median 7 months) and 57.1% (median 99 months), respectively. FISH analysis revealed 6 (43%) patients were positive for TP53 deletion (deletion group) and 8 (57%) were negative (non-deletion group). All six patients in the deletion group were diagnosed at an advanced stage; five were refractory to initial treatment, one relapsed after treatment, and all patients died of ALK + ALCL. The median PFS was 3.5 months in the deletion group and 76 months in the non-deletion group. The median OS was 7 months in the deletion group and has yet to be confirmed in the non-deletion group. OncoScan analysis showed TP53 copy number reduction in the deletion group and no TP53 copy number abnormalities in the non-deletion group. This study suggests that TP53 deletion is a poor prognostic factor in ALK + ALCL treated with CHOP-based therapy.