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<p>Pure red cell aplasia (PRCA) is a rare hematological disorder characterized by erythroid hypoplasia and maturation arrest in the bone marrow. We present a case of acquired PRCA secondary to smoldering multiple myeloma (SMM), initially presenting as severe anemia requiring multiple blood transfusions. This case highlights the diagnostic dilemma at presentation as well as the therapeutic challenges in treating PRCA secondary to SMM. Here we discuss the appropriate workup and identify a potential option for managing these patients with subcutaenous daratumumab.</p>

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Rare case of pure red cell aplasia secondary to smoldering multiple myeloma successfully treated with daratumumab – case report and review of the literature

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月19日

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  • Malak Alharbi,
  • Sawyer Bawek,
  • Ian Lund,
  • Sean T. Glenn,
  • Steven Green,
  • Hamza Hassan,
  • You-Wen Qian,
  • Jens Hillengass

摘要

Pure red cell aplasia (PRCA) is a rare hematological disorder characterized by erythroid hypoplasia and maturation arrest in the bone marrow. We present a case of acquired PRCA secondary to smoldering multiple myeloma (SMM), initially presenting as severe anemia requiring multiple blood transfusions. This case highlights the diagnostic dilemma at presentation as well as the therapeutic challenges in treating PRCA secondary to SMM. Here we discuss the appropriate workup and identify a potential option for managing these patients with subcutaenous daratumumab.