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<p>Myeloid sarcoma (MS) is an extramedullary localization of immature granulocyte cells that can occur in association with acute myeloid leukemia (AML). Gastrointestinal involvement is relatively common in MS, but exclusive colonic localization is a rare occurrence. Here, we report on a 53-year-old male patient affected by AML developing a severe abdominal pain caused by intestinal perforation requiring surgical intervention. The post-mortem examination revealed an infiltrate consistent with MS. Diagnosis of colonic MS can be difficult due to non-specific symptoms and complicated by the challenges associated with exploring this area. Clinical acumen is crucial to promptly establish adequate management due to the potentially life-threatening nature of this condition.</p>

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A fatal case of peritonitis due to colonic localization of acute myeloid leukemia

  • 期刊论文

  • 发表日期：

    2025年1月7日

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  • Elisa Buzzatti,
  • Caterina Botti,
  • Roberta Presicci,
  • Cristina Mauro,
  • Francesca Blasi,
  • Giovangiacinto Paterno,
  • Luca Savino,
  • Raffaele Palmieri,
  • Carmelo Gurnari,
  • Tiziana Ottone,
  • Flavia Mallegni,
  • Elisa Meddi,
  • Federico Moretti,
  • Ilaria Tiravanti,
  • Lucia Cardillo,
  • Valeria Mezzanotte,
  • Kristian Taka,
  • Lucrezia De Marchi,
  • Adriano Venditti,
  • Massimo Villa,
  • Maria Ilaria Del Principe

摘要

Myeloid sarcoma (MS) is an extramedullary localization of immature granulocyte cells that can occur in association with acute myeloid leukemia (AML). Gastrointestinal involvement is relatively common in MS, but exclusive colonic localization is a rare occurrence. Here, we report on a 53-year-old male patient affected by AML developing a severe abdominal pain caused by intestinal perforation requiring surgical intervention. The post-mortem examination revealed an infiltrate consistent with MS. Diagnosis of colonic MS can be difficult due to non-specific symptoms and complicated by the challenges associated with exploring this area. Clinical acumen is crucial to promptly establish adequate management due to the potentially life-threatening nature of this condition.