<p>Soil salinization is a global environmental concern that threatens food and nutritional security. In this study, the effectiveness of integrating a raised-bed planting system, mulching and drip irrigation for managing soil salinity was investigated in a wheat field experiment conducted from 2019 to 2020 and 2020–2021. The experimental design included two planting methods, namely, (a) flat-bed planting (FB) and (b) raised-bed planting (RB) methods along with rice straw mulch application. Furthermore, saline water at four salinity levels was applied in the subplot treatments via a drip irrigation system, with EC_iw values of (i) 12 dS m⁻¹, (ii) 9 dS m⁻¹, and (iii) 6 dS m⁻¹, as well as (iv) the best available water (BAW, ~ 4 dS m⁻¹), which served as a control. The findings revealed that the integration of drip irrigation, mulching, and the RB system favourably affected the soil–plant environment. The RB system not only increased the soil moisture content but also significantly reduced surface salinity by redistributing soluble salts towards bed slopes and furrows, thereby maintaining a relatively low salt concentration in the crop root zone. Additionally, the RB mulched drip-irrigated system yielded greater nitrogen (NO₃–N) availability, leaf area index (LAI) and canopy density levels. These favourable changes increased the grain yield, water productivity, net income and water economic productivity, which increased by 7%, 4.22%, 9.22% and 9.14%, respectively, compared with those in the FB mulched drip-irrigated system. This study revealed that the integration of drip irrigation, residue mulching, and RB systems could sustain crop production in arid and semiarid regions facing acute shortages of good-quality irrigation water.</p>