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Purpose <p>This study analyzed global interest in cryoneurolysis, a minimally invasive nerve ablation technique for non-opioid pain management, identifying temporal trends, geographic distribution, and commercial drivers influencing adoption.</p> Materials and Methods <p>Retrospective analysis of Google Trends data (January 2004-March 2025) and PubMed publications (1993–2025) using the keyword "cryoneurolysis." Statistical analyses included Mann–Kendall trend tests, Portmanteau white noise tests, Dickey–Fuller unit root tests, and Spearman correlations. Forecasting employed nonseasonal Holt-Winters smoothing and local polynomial regression.</p> Results <p>Search interest remained negligible (SVI = 0) from 2004 to mid-2019, with academic activity preceding public interest by 3–4&#xa0;years. Both datasets demonstrated significant upward trends (PubMed: τ = 0.80, p &lt; 0.0001; Google Trends: τ = 0.75, p &lt; 0.0001). Commercial driver "Iovera" showed perfect correlation (r = 1.0) with search volume. Geographic concentration was limited to six high-income countries. Forecasting projects sustained growth through 2030, with publications increasing from 46.1 (95% CI: 41.8–50.4) in 2025 to 72.6 (95% CI: 59.2–86.0) by 2030.</p> Conclusion <p>Analysis reveals parallel academic–public interest growth driven by commercial factors, geographic concentration in developed nations, and emerging applications in interventional radiology, suggesting wider adoption by 2030.</p>

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Cryoneurolysis: Parallel Growth in PubMed Publications and Google Trends Analysis Reveals Exponential Interest

  • 期刊论文

  • 发表日期：

    2025年7月10日

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  • Francois H. Cornelis,
  • Rozan Bokhari,
  • Ruben Geevarghese,
  • Dimitrios K. Filippiadis

摘要

Purpose

This study analyzed global interest in cryoneurolysis, a minimally invasive nerve ablation technique for non-opioid pain management, identifying temporal trends, geographic distribution, and commercial drivers influencing adoption.

Materials and Methods

Retrospective analysis of Google Trends data (January 2004-March 2025) and PubMed publications (1993–2025) using the keyword "cryoneurolysis." Statistical analyses included Mann–Kendall trend tests, Portmanteau white noise tests, Dickey–Fuller unit root tests, and Spearman correlations. Forecasting employed nonseasonal Holt-Winters smoothing and local polynomial regression.

Results

Search interest remained negligible (SVI = 0) from 2004 to mid-2019, with academic activity preceding public interest by 3–4 years. Both datasets demonstrated significant upward trends (PubMed: τ = 0.80, p < 0.0001; Google Trends: τ = 0.75, p < 0.0001). Commercial driver "Iovera" showed perfect correlation (r = 1.0) with search volume. Geographic concentration was limited to six high-income countries. Forecasting projects sustained growth through 2030, with publications increasing from 46.1 (95% CI: 41.8–50.4) in 2025 to 72.6 (95% CI: 59.2–86.0) by 2030.

Conclusion

Analysis reveals parallel academic–public interest growth driven by commercial factors, geographic concentration in developed nations, and emerging applications in interventional radiology, suggesting wider adoption by 2030.