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Purpose <p>To investigate the safety and efficacy of pharmacomechanical intervention in the maintenance of pediatric dialysis access fistulas and grafts in the extremities.</p> Materials and Methods <p>A retrospective analysis of 67 interventions performed on 17 pediatric patients with dialysis access maintenance interventions was conducted. Use of angioplasty, stenting, thrombectomy devices, and thrombolytic agents such as tissue plasminogen activator (tPA) were recorded across interventions. Total number of interventions per patient and time between reinterventions were measured. Safety of these techniques was assessed according to the Cardiovascular and Interventional Radiology Society of Europe (CIRSE) complication guidelines. Technical success was defined as restoration of patency without a hemodynamically significant stenosis, and clinical success was defined as symptom resolution without reintervention of greater than 6&#xa0;months.</p> Results <p>The application of pharmacomechanical intervention demonstrated a favorable safety profile and high technical success rates across all categories. The median age at first intervention was 13&#xa0;years (IQR 10.1–16.9, range 7–18), and median number of interventions was 2 with a range of 1–11. No major complications were observed during or after the procedures. Among the 67 interventions, angioplasty was the most frequently employed technique (<i>n = </i>67, 100%), followed by thrombolysis and/or anticoagulation (<i>n = </i>34, 50.7%), thrombectomy (<i>n = </i>21, 31.3%), and stenting (<i>n = </i>10, 14.9%). Technical success was 98.5% (66/67), and combined 6-month primary assisted and secondary patency from the index dialysis circuit intervention was 41.8% (28/67). For patients who received more than one treatment, median time to reintervention was 107&#xa0;days.</p> Conclusion <p>The high rate of technical success and absence of major or minor complications suggest that endovascular techniques for dialysis access maintenance including angioplasty, stenting, thrombolysis, and advances therapies can be safely and effectively performed in pediatric patients. Rates of primary and secondary patency are slightly lower compared to the adult population.</p> Level of Evidence <p>Level 4, Retrospective Cohort Study.</p> Graphic Abstract <p></p>

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Safety and Feasibility of Endovascular Management of Pediatric Dialysis Access

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月9日

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  • Jake DiFatta,
  • Chase Mahler,
  • Junjian Huang,
  • A. J. Gunn,
  • Junaid Raja

摘要

Purpose

To investigate the safety and efficacy of pharmacomechanical intervention in the maintenance of pediatric dialysis access fistulas and grafts in the extremities.

Materials and Methods

A retrospective analysis of 67 interventions performed on 17 pediatric patients with dialysis access maintenance interventions was conducted. Use of angioplasty, stenting, thrombectomy devices, and thrombolytic agents such as tissue plasminogen activator (tPA) were recorded across interventions. Total number of interventions per patient and time between reinterventions were measured. Safety of these techniques was assessed according to the Cardiovascular and Interventional Radiology Society of Europe (CIRSE) complication guidelines. Technical success was defined as restoration of patency without a hemodynamically significant stenosis, and clinical success was defined as symptom resolution without reintervention of greater than 6 months.

Results

The application of pharmacomechanical intervention demonstrated a favorable safety profile and high technical success rates across all categories. The median age at first intervention was 13 years (IQR 10.1–16.9, range 7–18), and median number of interventions was 2 with a range of 1–11. No major complications were observed during or after the procedures. Among the 67 interventions, angioplasty was the most frequently employed technique (n = 67, 100%), followed by thrombolysis and/or anticoagulation (n = 34, 50.7%), thrombectomy (n = 21, 31.3%), and stenting (n = 10, 14.9%). Technical success was 98.5% (66/67), and combined 6-month primary assisted and secondary patency from the index dialysis circuit intervention was 41.8% (28/67). For patients who received more than one treatment, median time to reintervention was 107 days.

Conclusion

The high rate of technical success and absence of major or minor complications suggest that endovascular techniques for dialysis access maintenance including angioplasty, stenting, thrombolysis, and advances therapies can be safely and effectively performed in pediatric patients. Rates of primary and secondary patency are slightly lower compared to the adult population.

Level of Evidence

Level 4, Retrospective Cohort Study.

Graphic Abstract