<p>Water hyacinth is among the world’s most damaging aquatic invasive plants, forming dense mats that disrupt ecosystem functioning, fisheries, navigation, and livelihoods across tropical and subtropical freshwater systems. Its rapid spread is driven by clonal propagation, short life cycles, and prolific seed production, particularly under nutrient-enriched conditions. Although mechanical, chemical, and biological control methods are widely applied, their long-term effectiveness remains uncertain when underlying eutrophication persists. Here, we present a large-scale, one-time water hyacinth removal campaign in Lake Tana, Ethiopia’s largest lake and a UNESCO Biosphere Reserve, as a representative nutrient-rich tropical freshwater system. Using high-resolution satellite imagery, we quantified coverage one month before removal, one month after removal, and one year later. We integrated SWOT (Strengths, Weaknesses, Opportunities, Threats) analysis with a socio-ecological system map to assess mitigation mechanisms and identify sustainable management pathways capable of providing long-term solutions to halt water hyacinth proliferation in freshwater bodies. The campaign removed over 75% (~1271 ha) of water hyacinth, yet within one year the plant resurged to levels ~18% higher than pre-removal. This rebound highlights the ecological resilience of water hyacinth and the limitations of short term, noncontinuous control strategies. Our analysis identifies unmanaged catchment nutrient inputs as the primary driver of proliferation. Lake Tana serves as a model system demonstrating that water hyacinth functions less as a traditional invader and more as a bioindicator of eutrophication. We propose a transferable conceptual and methodological framework combining continuous removal, catchment-based nutrient management, and circular bioeconomy approaches, offering globally relevant lessons for sustainable management of nutrient-enriched tropical freshwater systems.</p>