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Background <p>Although multimodal aesthetic treatments are used, the combined effects of botulinum toxin A and hyaluronic acid skinbooster for periorbital rejuvenation have not been properly evaluated. This study assessed the efficacy and durability of associating abobotulinumtoxinA and Restylane<sup>®</sup> Skinbooster Vital for the treatment of canthal lines.</p> Methods <p>Twenty-four Brazilian women with dynamic periorbital wrinkles (Merz 5-point scale, levels II-IV) participated in this randomized, double-blinded, split-face trial. After bilateral abobotulinumtoxinA injections, one side of the face was randomized to receive Restylane<sup>®</sup> Skinbooster Vital, and the contralateral side underwent a simulated injection. Electromyography (EMG) activity, wrinkle severity, skin texture, and satisfaction with treatments were assessed at baseline and at 1, 2, 3, and 6 months. Data were analyzed using two-way repeated measures ANOVA, Bonferroni’s post-hoc tests, and the Mann-Whitney U test.</p> Results <p>EMG showed significant reductions over time, with no differences between treatments&#xa0;protocols (<i>p</i> &gt; 0.05). For canthal wrinkle severity, the combined protocol (AbobotulinumtoxinA + Restylane® Skinbooster Vital) demonstrated lower scores at 3 months (<i>p</i> = 0.0001) and 6 months (<i>p</i> = 0.003) compared with AbobotulinumtoxinA alone, as reported by patients. Skin texture progressively improved following Restylane® Skinbooster Vital application, remaining significantly higher at 3 (<i>p</i> = 0.0001) and 6 months (<i>p</i> = 0.002) when compared with AbobotulinumtoxinA alone. Patient satisfaction increased in both protocols, with superior results at 3 months in the combined protocol group (<i>p</i> = 0.009).</p> Conclusion <p>The association of abobotulinumtoxinA with Restylane® Skinbooster Vital provides enhanced and lasting improvements in severe canthal wrinkles.</p> Level of Evidence I <p>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors <a href="http://www.springer.com/00266">www.springer.com/00266</a>.</p>

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Association of AbobotulinumtoxinA and Skinbooster for Periorbital Wrinkles: A Randomized, Controlled, Double-Blind, Split-Face Study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月8日

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  • Ana Claudia Laureano Navarro Shishido,
  • Livia Leão Leite Tostes,
  • Bryanne Brissian de Souza Nobre,
  • Jacqueline Rosa Gonçalves,
  • Lucas Alexandre de Sousa Mendes,
  • Ana Claudia Carbone,
  • Alfonso Sánchez-Ayala,
  • Mariana Barbosa Câmara-Souza,
  • Giancarlo De la Torre Canales

摘要

Background

Although multimodal aesthetic treatments are used, the combined effects of botulinum toxin A and hyaluronic acid skinbooster for periorbital rejuvenation have not been properly evaluated. This study assessed the efficacy and durability of associating abobotulinumtoxinA and Restylane® Skinbooster Vital for the treatment of canthal lines.

Methods

Twenty-four Brazilian women with dynamic periorbital wrinkles (Merz 5-point scale, levels II-IV) participated in this randomized, double-blinded, split-face trial. After bilateral abobotulinumtoxinA injections, one side of the face was randomized to receive Restylane® Skinbooster Vital, and the contralateral side underwent a simulated injection. Electromyography (EMG) activity, wrinkle severity, skin texture, and satisfaction with treatments were assessed at baseline and at 1, 2, 3, and 6 months. Data were analyzed using two-way repeated measures ANOVA, Bonferroni’s post-hoc tests, and the Mann-Whitney U test.

Results

EMG showed significant reductions over time, with no differences between treatments protocols (p > 0.05). For canthal wrinkle severity, the combined protocol (AbobotulinumtoxinA + Restylane® Skinbooster Vital) demonstrated lower scores at 3 months (p = 0.0001) and 6 months (p = 0.003) compared with AbobotulinumtoxinA alone, as reported by patients. Skin texture progressively improved following Restylane® Skinbooster Vital application, remaining significantly higher at 3 (p = 0.0001) and 6 months (p = 0.002) when compared with AbobotulinumtoxinA alone. Patient satisfaction increased in both protocols, with superior results at 3 months in the combined protocol group (p = 0.009).

Conclusion

The association of abobotulinumtoxinA with Restylane® Skinbooster Vital provides enhanced and lasting improvements in severe canthal wrinkles.

Level of Evidence I

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.